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Query: NC_003997:4473973:4488601 Bacillus anthracis str. Ames, complete genome

Start: 4488601, End: 4488945, Length: 345

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4474000:448862844886284488972345Bacillus anthracis str. A0248, complete genomehypothetical protein4e-61233
NC_012581:4478036:449015244901524490496345Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein4e-61233
NC_005945:4473790:448929044892904489634345Bacillus anthracis str. Sterne, complete genomehypothetical protein4e-61233
NC_007530:4474000:448872844887284489072345Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein4e-61233
NC_011773:4541306:455215045521504552494345Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-60230
NC_014335:4414052:442279344227934423137345Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein2e-59227
NC_017200:4484399:449911744991174499461345Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein2e-58224
NC_005957:4472800:448380344838034484147345Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein1e-58224
NC_010184:4497473:451360845136084513952345Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein8e-55211
NC_011725:4636521:465243046524304652774345Bacillus cereus B4264 chromosome, complete genomehypothetical protein9e-55211
NC_011969:4396000:441123044112304411574345Bacillus cereus Q1 chromosome, complete genomehypothetical protein3e-54210
NC_011772:4606000:461832246183224618666345Bacillus cereus G9842, complete genomehypothetical protein1e-53207
NC_004722:4614442:462815346281534628497345Bacillus cereus ATCC 14579, complete genomehypothetical protein4e-53206
NC_017208:4662500:467335246733524673696345Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein7e-53205