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Query: NC_003997:4473973:4479825 Bacillus anthracis str. Ames, complete genome

Start: 4479825, End: 4480259, Length: 435

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4474000:447985244798524480286435Bacillus anthracis str. A0248, complete genomeputative lipoprotein3e-60229
NC_005945:4473790:448051444805144480948435Bacillus anthracis str. Sterne, complete genomelipoprotein, putative3e-60229
NC_007530:4474000:447995244799524480386435Bacillus anthracis str. 'Ames Ancestor', complete genomelipoprotein, putative3e-60229
NC_011773:4541306:454245845424584542892435Bacillus cereus AH820 chromosome, complete genomeputative lipoprotein1e-59228
NC_005957:4472800:447395244739524474386435Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein1e-59228
NC_012581:4478036:448135244813524481783432Bacillus anthracis str. CDC 684 chromosome, complete genomeputative lipoprotein2e-59227
NC_004722:4614442:461776346177634618197435Bacillus cereus ATCC 14579, complete genomehypothetical protein8e-53205