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Query: NC_003997:4473973:4477973 Bacillus anthracis str. Ames, complete genome

Start: 4477973, End: 4478485, Length: 513

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017200:4484399:448786944878694488381513Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein9e-61232
NC_012659:4474000:447800044780004478512513Bacillus anthracis str. A0248, complete genomehypothetical protein9e-61232
NC_012581:4478036:447949644794964480008513Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein9e-61232
NC_011969:4396000:440047944004794400991513Bacillus cereus Q1 chromosome, complete genomehypothetical protein9e-61232
NC_007530:4474000:447810044781004478612513Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein9e-61232
NC_005945:4473790:447866244786624479174513Bacillus anthracis str. Sterne, complete genomehypothetical protein9e-61232
NC_010184:4497473:450076945007694501278510Bacillus weihenstephanensis KBAB4, complete genomeprotein of unknown function DUF9481e-59228
NC_011725:4636521:464071946407194641231513Bacillus cereus B4264 chromosome, complete genomehypothetical protein9e-59225
NC_004722:4614442:461590846159084616420513Bacillus cereus ATCC 14579, complete genomeGeneral stress protein9e-59225
NC_017353:1235095:124863712486371249107471Staphylococcus lugdunensis N920143, complete genomehypothetical protein1e-22105
NC_014915:2900209:292016529201652920578414Geobacillus sp. Y412MC52 chromosome, complete genomeprotein of unknown function DUF9485e-1167
NC_013411:681907:683357683357683770414Geobacillus sp. Y412MC61, complete genomeprotein of unknown function DUF9485e-1167