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Query: NC_003997:4473973:4477647 Bacillus anthracis str. Ames, complete genome

Start: 4477647, End: 4477973, Length: 327

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005945:4473790:447833644783364478665330Bacillus anthracis str. Sterne, complete genomehypothetical protein6e-50195
NC_012659:4474000:447767444776744478000327Bacillus anthracis str. A0248, complete genomehypothetical protein7e-50195
NC_012581:4478036:447917044791704479496327Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein7e-50195
NC_007530:4474000:447777444777744478100327Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein7e-50195
NC_011969:4396000:440015344001534400479327Bacillus cereus Q1 chromosome, complete genomehypothetical protein1e-48191
NC_017200:4484399:448754344875434487869327Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein2e-48190
NC_011725:4636521:464039346403934640719327Bacillus cereus B4264 chromosome, complete genomehypothetical protein9e-48188
NC_004722:4614442:461558246155824615911330Bacillus cereus ATCC 14579, complete genomehypothetical Cytosolic Protein8e-48188
NC_010184:4497473:450044045004404500766327Bacillus weihenstephanensis KBAB4, complete genomeconserved hypothetical cytosolic protein2e-44177
NC_013411:681907:684187684187684516330Geobacillus sp. Y412MC61, complete genomehypothetical protein9e-2199
NC_014915:2900209:291941929194192919748330Geobacillus sp. Y412MC52 chromosome, complete genomehypothetical protein9e-2199
NC_014225:1403007:142664514266451426950306Waddlia chondrophila WSU 86-1044 chromosome, complete genomehypothetical protein9e-1372.4
NC_020054:5023996:504568250456825046098417Fibrella aestuarina BUZ 2 drat genomehypothetical protein3e-1270.9