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Query: NC_003997:4399067:4416885 Bacillus anthracis str. Ames, complete genome

Start: 4416885, End: 4417388, Length: 504

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016771:4333000:434845243484524348955504Bacillus cereus NC7401, complete genomehypothetical protein2e-81300
NC_010184:4425676:444243644424364442939504Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein4e-73273
NC_012659:4399094:441691244169124417415504Bacillus anthracis str. A0248, complete genomehypothetical protein7e-83305
NC_014335:4327584:434539243453924345895504Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein7e-83305
NC_016779:4361140:437909943790994379602504Bacillus cereus F837/76 chromosome, complete genomehypothetical protein2e-81300
NC_012472:4400420:441444044144404414943504Bacillus cereus 03BB102, complete genomehypothetical protein2e-81300
NC_007530:4400152:441701244170124417515504Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein7e-83305
NC_017200:4401945:442084644208464421349504Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein2e-81300
NC_011658:4379274:439466943946694395172504Bacillus cereus AH187 chromosome, complete genomehypothetical protein2e-81300
NC_005945:4399756:441757444175744418077504Bacillus anthracis str. Sterne, complete genomehypothetical protein7e-83305
NC_011725:4562709:457676345767634577266504Bacillus cereus B4264 chromosome, complete genomehypothetical protein2e-81300
NC_014171:4447856:446590544659054466204300Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein1e-47189
NC_011773:4461758:447861844786184479121504Bacillus cereus AH820 chromosome, complete genomehypothetical protein7e-83305
NC_006274:4448293:446529244652924465795504Bacillus cereus E33L, complete genomehypothetical protein1e-81301