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Query: NC_003997:4399067:4416550 Bacillus anthracis str. Ames, complete genome

Start: 4416550, End: 4416888, Length: 339

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4399094:441657744165774416915339Bacillus anthracis str. A0248, complete genomehypothetical protein1e-57221
NC_011773:4461758:447828344782834478621339Bacillus cereus AH820 chromosome, complete genomehypothetical protein1e-57221
NC_005945:4399756:441723944172394417577339Bacillus anthracis str. Sterne, complete genomehypothetical protein1e-57221
NC_014335:4327584:434505743450574345395339Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein1e-57221
NC_007530:4400152:441667744166774417015339Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein1e-57221
NC_006274:4448293:446495744649574465295339Bacillus cereus E33L, complete genomehypothetical protein4e-57219
NC_012472:4400420:441410544141054414443339Bacillus cereus 03BB102, complete genomehypothetical protein4e-57219
NC_011658:4379274:439433443943344394672339Bacillus cereus AH187 chromosome, complete genomehypothetical protein4e-57219
NC_016779:4361140:437876443787644379102339Bacillus cereus F837/76 chromosome, complete genomehypothetical protein4e-57219
NC_017200:4401945:442051144205114420849339Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein4e-57219
NC_016771:4333000:434811143481114348455345Bacillus cereus NC7401, complete genomehypothetical protein3e-57219
NC_014171:4447856:446536644653664465704339Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein1e-56218
NC_011725:4562709:457642845764284576766339Bacillus cereus B4264 chromosome, complete genomehypothetical protein1e-56218
NC_010184:4425676:444210144421014442439339Bacillus weihenstephanensis KBAB4, complete genomeconserved hypothetical membrane spanning protein1e-56218
NC_009012:75000:976299762997967339Clostridium thermocellum ATCC 27405, complete genomehypothetical protein1e-1375.1