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Query: NC_003997:4399067:4403014 Bacillus anthracis str. Ames, complete genome

Start: 4403014, End: 4403475, Length: 462

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010694:1966676:198440019844001984846447Erwinia tasmaniensis, complete genomeConserved hypothetical protein YeaL1e-1065.5
NC_006274:4448293:445128244512824451743462Bacillus cereus E33L, complete genomeconserved hypothetical protein; possible membrane spanning protein2e-59227
NC_016771:4333000:433459343345934335054462Bacillus cereus NC7401, complete genomehypothetical protein2e-59227
NC_005945:4399756:440370344037034404164462Bacillus anthracis str. Sterne, complete genomehypothetical protein2e-59227
NC_009674:3344000:334874233487423349203462Bacillus cytotoxicus NVH 391-98 chromosome, complete genomehypothetical protein2e-54211
NC_009053:393700:411911411911412363453Actinobacillus pleuropneumoniae L20, complete genomehypothetical protein7e-1166.2
NC_016779:4361140:436508743650874365548462Bacillus cereus F837/76 chromosome, complete genomehypothetical protein2e-59227
NC_011658:4379274:438081043808104381271462Bacillus cereus AH187 chromosome, complete genomehypothetical protein2e-59227
NC_012472:4400420:440042044004204400881462Bacillus cereus 03BB102, complete genomehypothetical protein2e-59227
NC_010939:405477:439693439693440145453Actinobacillus pleuropneumoniae serovar 7 str. AP76, completehypothetical protein7e-1166.2
NC_014328:1108479:112377511237751124239465Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein2e-0755.1
NC_011773:4461758:446474744647474465208462Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-59227
NC_011725:4562709:456270945627094563170462Bacillus cereus B4264 chromosome, complete genomehypothetical protein3e-59226
NC_010278:398521:416638416638417090453Actinobacillus pleuropneumoniae serovar 3 str. JL03 chromosome,hypothetical protein7e-1166.2
NC_012659:4399094:440304144030414403502462Bacillus anthracis str. A0248, complete genomehypothetical protein2e-59227
NC_007530:4400152:440314144031414403602462Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-59227
NC_014171:4447856:445180344518034452165363Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein4e-49192
NC_010184:4425676:442866444286644429125462Bacillus weihenstephanensis KBAB4, complete genomeprotein of unknown function DUF4412e-59227
NC_013850:3303500:330358633035863304032447Klebsiella variicola At-22 chromosome, complete genomeprotein of unknown function DUF4411e-1065.5
NC_017200:4401945:440710744071074407568462Bacillus thuringiensis serovar finitimus YBT-020 chromosome,putative membrane spanning protein6e-59226
NC_014335:4327584:433153143315314331992462Bacillus cereus biovar anthracis str. CI chromosome, completeputative membrane spanning protein2e-59227