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Query: NC_003997:4273579:4284229 Bacillus anthracis str. Ames, complete genome

Start: 4284229, End: 4285227, Length: 999

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012472:4255729:428896042889604289958999Bacillus cereus 03BB102, complete genomehypothetical protein0648
NC_012659:4273606:428425642842564285254999Bacillus anthracis str. A0248, complete genomehypothetical protein0647
NC_014335:4181710:421494542149454215943999Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein0646
NC_011969:4140000:417213941721394173137999Bacillus cereus Q1 chromosome, complete genometpr repeat protein1e-180632
NC_017208:4435573:445970444597044460702999Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein7e-174609
NC_014171:4317520:434503743450374346035999Bacillus thuringiensis BMB171 chromosome, complete genomeTPR repeat-containing protein7e-174609
NC_004722:4405363:443012844301284431126999Bacillus cereus ATCC 14579, complete genomeTPR repeat protein7e-174609