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Query: NC_003997:3462497:3474808 Bacillus anthracis str. Ames, complete genome

Start: 3474808, End: 3475086, Length: 279

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007530:3462624:347493534749353475213279Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein1e-46184
NC_012659:3464500:347483534748353475107273Bacillus anthracis str. A0248, complete genomehypothetical protein4e-45179
NC_012581:755982:763482763482763754273Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein4e-45179
NC_005945:3463199:347551034755103475782273Bacillus anthracis str. Sterne, complete genomehypothetical protein4e-45179
NC_010184:3464707:348696734869673487239273Bacillus weihenstephanensis KBAB4, complete genomeuncharacterized phage protein (possible DNA packaging)4e-44176
NC_007530:467993:469453469453469725273Bacillus anthracis str. 'Ames Ancestor', complete genomeprophage lambdaba04, dna packaging protein, putative3e-31133
NC_005945:467427:469496469496469768273Bacillus anthracis str. Sterne, complete genomeprophage LambdaBa04, DNA packaging protein, putative3e-31133
NC_003997:467993:469453469453469725273Bacillus anthracis str. Ames, complete genomeprophage LambdaBa04, DNA packaging protein, putative3e-31133
NC_012659:467893:469353469353469625273Bacillus anthracis str. A0248, complete genomeputative prophage LambdaBa04, DNA packaging protein3e-31133
NC_016894:3988180:398851639885163988818303Acetobacterium woodii DSM 1030 chromosome, complete genomeputative prophage LambdaBa04 DNA packaging protein9e-1992
NC_016894:3580274:358222635822263582528303Acetobacterium woodii DSM 1030 chromosome, complete genomeputative prophage LambdaBa04 DNA packaging protein9e-1992
NC_012914:1824955:183888518388851839184300Paenibacillus sp. JDR-2, complete genomeputative phage protein (for DNA packaging)2e-1787.4
NC_020291:1122282:113135811313581131639282Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomephage protein2e-1684
NC_014393:2868846:288390328839032884178276Clostridium cellulovorans 743B chromosome, complete genomehypothetical protein3e-1477.4
NC_009617:1085000:109516110951611095445285Clostridium beijerinckii NCIMB 8052 chromosome, complete genomephage protein3e-1167