Pre_GI: BLASTP Hits

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Query: NC_003997:3462497:3473837 Bacillus anthracis str. Ames, complete genome

Start: 3473837, End: 3474166, Length: 330

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:3464500:347386434738643474193330Bacillus anthracis str. A0248, complete genomehypothetical protein4e-50196
NC_012581:755982:764396764396764725330Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein4e-50196
NC_005945:3463199:347453934745393474868330Bacillus anthracis str. Sterne, complete genomehypothetical protein4e-50196
NC_007530:3462624:347396434739643474293330Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein4e-50196
NC_010184:3464707:348599634859963486325330Bacillus weihenstephanensis KBAB4, complete genomeprophage pi2 protein 381e-49194
NC_010184:3631891:364743136474313647766336Bacillus weihenstephanensis KBAB4, complete genomeprophage pi2 protein 381e-39161
NC_011772:3749399:376030037603003760635336Bacillus cereus G9842, complete genomeprophage pi2 protein 384e-39159
NC_011772:2495972:249995424999542500283330Bacillus cereus G9842, complete genomeprophage pi2 protein 382e-38157
NC_005945:467427:470410470410470739330Bacillus anthracis str. Sterne, complete genomehypothetical protein1e-35148
NC_003997:467993:470367470367470696330Bacillus anthracis str. Ames, complete genomehypothetical protein1e-35148
NC_007530:467993:470367470367470696330Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein1e-35148
NC_018704:176088:211809211809212123315Amphibacillus xylanus NBRC 15112, complete genomehypothetical protein2e-27120
NC_012659:467893:470402470402470596195Bacillus anthracis str. A0248, complete genomehypothetical protein2e-1788.2
NC_014376:787460:824962824962825294333Clostridium saccharolyticum WM1 chromosome, complete genomehypothetical protein2e-1477.8
NC_007432:654904:686364686364686690327Streptococcus agalactiae A909, complete genomehypothetical protein1e-1375.1
NC_003212:2592600:259994425999442600267324Listeria innocua Clip11262, complete genomehypothetical protein1e-1271.6
NC_002662:1042546:105955110595511059868318Lactococcus lactis subsp. lactis Il1403, complete genomeprophage pi2 protein 384e-1270.1
NC_008555:1204000:123184812318481232171324Listeria welshimeri serovar 6b str. SLCC5334, complete genomeconserved phage-related protein1e-1168.6
NC_014393:2868846:288290628829062883232327Clostridium cellulovorans 743B chromosome, complete genomephage related protein6e-0856.2