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Query: NC_003997:3320906:3332943 Bacillus anthracis str. Ames, complete genome

Start: 3332943, End: 3333425, Length: 483

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:3320933:333297033329703333452483Bacillus anthracis str. A0248, complete genomehypothetical protein7e-85312
NC_012581:897957:905190905190905672483Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein7e-85312
NC_005945:3321600:333363733336373334119483Bacillus anthracis str. Sterne, complete genomehypothetical protein7e-85312
NC_007530:3321033:333307033330703333552483Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein7e-85312
NC_011773:3399531:341266334126633413145483Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-84310
NC_014976:759129:792551792551793033483Bacillus subtilis BSn5 chromosome, complete genomehypothetical protein3e-50197
NC_006270:2657726:266068726606872661166480Bacillus licheniformis ATCC 14580, complete genomeconserved protein YrhD1e-44178
NC_006322:2658587:266154826615482662027480Bacillus licheniformis ATCC 14580, complete genomeYrhD1e-44178
NC_006322:2173500:217957121795712180131561Bacillus licheniformis ATCC 14580, complete genomeYjgD3e-1891.3
NC_006270:2172693:217872521787252179285561Bacillus licheniformis ATCC 14580, complete genomehypothetical protein3e-1891.3
NC_014639:725577:748347748347748907561Bacillus atrophaeus 1942 chromosome, complete genomehypothetical protein3e-1477.4
CP002207:725577:748347748347748907561Bacillus atrophaeus 1942, complete genomehypothetical protein3e-1477.4