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Query: NC_003997:2175843:2192469 Bacillus anthracis str. Ames, complete genome

Start: 2192469, End: 2192726, Length: 258

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007530:2175967:219259321925932192850258Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein7e-1889.4
NC_012659:2175867:219249321924932192750258Bacillus anthracis str. A0248, complete genomehypothetical protein7e-1889.4
NC_005945:2175871:219257521925752192832258Bacillus anthracis str. Sterne, complete genomehypothetical protein7e-1889.4
NC_012472:2240000:225623022562302256487258Bacillus cereus 03BB102, complete genomehypothetical protein1e-1685.1
NC_011658:2275864:229195422919542292211258Bacillus cereus AH187 chromosome, complete genomehypothetical protein3e-1684
NC_011773:2239753:225642322564232256680258Bacillus cereus AH820 chromosome, complete genomehypothetical protein7e-1889.4
NC_011725:2206000:222289922228992223156258Bacillus cereus B4264 chromosome, complete genomehypothetical protein2e-1788.2
NC_014335:2151404:216876021687602169017258Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein7e-1889.4
NC_011772:2166000:218246621824662182723258Bacillus cereus G9842, complete genomehypothetical protein2e-1788.2
NC_014171:2177353:219504321950432195300258Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein2e-1788.2
NC_005957:2196000:221212422121242212381258Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein7e-1889.4