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Query: NC_003997:1334000:1338734 Bacillus anthracis str. Ames, complete genome

Start: 1338734, End: 1338970, Length: 237

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:1334000:133875713387571338993237Bacillus anthracis str. A0248, complete genomehypothetical protein7e-31132
NC_012581:2885519:290010229001022900338237Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein7e-31132
NC_005945:1334000:133880313388031339039237Bacillus anthracis str. Sterne, complete genomehypothetical protein7e-31132
NC_007530:1332768:133885713388571339093237Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein7e-31132
NC_012472:1339500:134179613417961342011216Bacillus cereus 03BB102, complete genomehypothetical protein1e-24112
NC_016779:1321723:132538113253811325596216Bacillus cereus F837/76 chromosome, complete genomehypothetical protein1e-24112
NC_008600:1396471:139875213987521398949198Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein2e-24110
NC_011773:1402155:140443614044361404606171Bacillus cereus AH820 chromosome, complete genomehypothetical protein4e-1993.2
NC_016771:1397292:140309614030961403266171Bacillus cereus NC7401, complete genomehypothetical protein6e-1992.8
NC_011658:1437813:144361714436171443787171Bacillus cereus AH187 chromosome, complete genomehypothetical protein6e-1992.8
NC_011725:1383798:138990213899021390072171Bacillus cereus B4264 chromosome, complete genomehypothetical protein3e-1787