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Query: NC_003997:1334000:1338435 Bacillus anthracis str. Ames, complete genome

Start: 1338435, End: 1338674, Length: 240

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:1334000:133845813384581338697240Bacillus anthracis str. A0248, complete genomehypothetical protein8e-41165
NC_012581:2885519:290039829003982900637240Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein8e-41165
NC_007530:1332768:133855813385581338797240Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein8e-41165
NC_005945:1334000:133850413385041338743240Bacillus anthracis str. Sterne, complete genomehypothetical protein8e-41165
NC_008600:1396471:139845313984531398710258Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein2e-40164
NC_016779:1321723:132508213250821325321240Bacillus cereus F837/76 chromosome, complete genomehypothetical protein2e-40164
NC_011773:1402155:140413714041371404376240Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-40164
NC_012472:1339500:134149713414971341736240Bacillus cereus 03BB102, complete genomehypothetical protein2e-40164
NC_011658:1437813:144331814433181443557240Bacillus cereus AH187 chromosome, complete genomehypothetical protein8e-40162
NC_016771:1397292:140279714027971403036240Bacillus cereus NC7401, complete genomehypothetical protein8e-40162
NC_006274:1367377:137315813731581373397240Bacillus cereus E33L, complete genomegroup-specific protein6e-40162
NC_011969:1437514:144301914430191443258240Bacillus cereus Q1 chromosome, complete genomehypothetical protein9e-40161
NC_017208:1380870:138339613833961383635240Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein9e-39158
NC_014171:1356000:136140113614011361640240Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein9e-39158
NC_011772:1329730:133301613330161333255240Bacillus cereus G9842, complete genomehypothetical protein9e-39158
NC_011725:1383798:138960013896001389842243Bacillus cereus B4264 chromosome, complete genomehypothetical protein2e-37154
NC_004722:1352000:135780913578091358051243Bacillus cereus ATCC 14579, complete genomehypothetical protein2e-37154
NC_010184:1373375:137679513767951377034240Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein9e-36148
NC_014335:1329414:133520913352091335382174Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein3e-27120