Pre_GI: BLASTP Hits

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Query: NC_003997:1334000:1337603 Bacillus anthracis str. Ames, complete genome

Start: 1337603, End: 1337716, Length: 114

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016779:1321723:132425013242501324363114Bacillus cereus F837/76 chromosome, complete genomehypothetical protein2e-1374.7
NC_012659:1334000:133762613376261337739114Bacillus anthracis str. A0248, complete genomehypothetical protein2e-1374.7
NC_012581:2885519:290135629013562901469114Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein2e-1374.7
NC_011773:1402155:140330514033051403418114Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-1374.7
NC_007530:1332768:133772613377261337839114Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-1374.7
NC_012472:1339500:134066513406651340778114Bacillus cereus 03BB102, complete genomehypothetical protein2e-1374.7
NC_011772:1329730:133222413322241332337114Bacillus cereus G9842, complete genomehypothetical protein2e-1374.3
NC_010184:1373375:137592713759271376040114Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein2e-1374.3
NC_011658:1437813:144247714424771442590114Bacillus cereus AH187 chromosome, complete genomehypothetical protein2e-1374.3
NC_011969:1437514:144217814421781442291114Bacillus cereus Q1 chromosome, complete genomehypothetical protein2e-1374.3
NC_016771:1397292:140195614019561402069114Bacillus cereus NC7401, complete genomehypothetical protein2e-1374.3
NC_017208:1380870:138260813826081382721114Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein3e-1270.5
NC_011725:1383798:138880713888071388920114Bacillus cereus B4264 chromosome, complete genomehypothetical protein3e-1270.5