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Query: NC_003997:1068000:1089169 Bacillus anthracis str. Ames, complete genome

Start: 1089169, End: 1090287, Length: 1119

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007530:1068000:1089169108916910902871119Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein0746
NC_003909:1205605:1225718122571812268361119Bacillus cereus ATCC 10987, complete genomehypothetical protein0701
NC_019897:3810000:3857358385735838585931236Thermobacillus composti KWC4 chromosome, complete genomehypothetical protein1e-1688.2
NC_004193:1335626:133851413385141339503990Oceanobacillus iheyensis HTE831, complete genomehypothetical protein4e-1582.8
NC_015660:1918307:1920392192039219214561065Geobacillus thermoglucosidasius C56-YS93 chromosome, completehypothetical protein5e-1272.4
NC_014650:1893758:1896953189695318980171065Geobacillus sp. Y4.1MC1 chromosome, complete genomehypothetical protein8e-1271.6
NC_006510:1731939:1753392175339217544561065Geobacillus kaustophilus HTA426, complete genomehypothetical protein7e-1271.6
NC_014209:1392115:140647014064701407429960Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,hypothetical protein2e-0860.5
NC_010320:1860801:186566118656611866620960Thermoanaerobacter sp. X514 chromosome, complete genomehypothetical protein4e-0755.8
NC_014538:1075720:108772410877241088683960Thermoanaerobacter sp. X513 chromosome, complete genomehypothetical protein4e-0755.8
NC_010321:947233:959222959222960181960Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completehypothetical protein5e-0755.8
NC_014964:923681:951415951415952374960Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completehypothetical protein5e-0755.8