Pre_GI: BLASTP Hits

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Query: NC_003888:8594500:8595004 Streptomyces coelicolor A3(2), complete genome

Start: 8595004, End: 8595444, Length: 441

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015953:6212366:625004662500466250486441Streptomyces sp. SirexAA-E chromosome, complete genomeMarR family transcriptional regulator1e-75280
NC_008278:925231:940959940959941405447Frankia alni ACN14a, complete genomeputative transcriptional regulator5e-2096.3
NC_015519:245036:255286255286255753468Tepidanaerobacter sp. Re1 chromosome, complete genomeMarR family transcriptional regulator2e-0754.7
NC_014210:1588426:160868616086861609114429Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 chromosome,transcriptional regulator, MarR family7e-0752.8
NC_009778:1717458:174751417475141748005492Enterobacter sakazakii ATCC BAA-894, complete genomehypothetical protein2e-0651.2
NC_014328:4546390:456014745601474560623477Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative MarR family transcriptional regulator3e-0650.4
NC_015711:3122000:314673031467303147248519Myxococcus fulvus HW-1 chromosome, complete genomeMarR family transcriptional regulator7e-0649.3
NC_015976:2023540:205303420530342053465432Sphingobium sp. SYK-6, complete genomeMarR family transcriptional regulator9e-0648.9