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Query: NC_003888:5114147:5116372 Streptomyces coelicolor A3(2), complete genome

Start: 5116372, End: 5116728, Length: 357

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003888:6470909:648496564849656485303339Streptomyces coelicolor A3(2), complete genomehypothetical protein1e-44177
NC_015957:7408466:741054774105477410873327Streptomyces violaceusniger Tu 4113 chromosome, complete genomeregulatory protein MerR3e-43173
NC_003155:365500:381592381592381924333Streptomyces avermitilis MA-4680, complete genomeMerR-family transcriptional regulator6e-43172
NC_008278:7409711:742790574279057428297393Frankia alni ACN14a, complete genomehypothetical protein2e-39160
NC_015953:2349503:238277723827772383112336Streptomyces sp. SirexAA-E chromosome, complete genomeMerR family transcriptional regulator3e-37153
NC_013595:480000:486612486612486938327Streptosporangium roseum DSM 43021, complete genomeputative transcriptional regulator, MerR family3e-36149
NC_015434:3581001:359433635943363594653318Verrucosispora maris AB-18-032 chromosome, complete genomeregulatory protein merr6e-33139
NC_014391:621062:625129625129625425297Micromonospora aurantiaca ATCC 27029 chromosome, complete genomeregulatory protein MerR9e-33138
NC_013947:3785332:378997737899773790285309Stackebrandtia nassauensis DSM 44728 chromosome, complete genometranscriptional regulator, MerR family6e-1992.8