Pre_GI: BLASTN Hits

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Query: NC_003366:2356148 Clostridium perfringens str. 13, complete genome

Start: 2356148, End: 2381797, Length: 25650

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_008262:22424322242432226666224231Clostridium perfringens SM101, complete genome07357BLASTN svgBLASTP svg
NC_008593:10605481060548108560225055Clostridium novyi NT, complete genome1e-116428BLASTN svgBLASTP svg
NC_008593:15131071513107153682423718Clostridium novyi NT, complete genome1e-107398BLASTN svgBLASTP svg
NC_021182:29210002921000295537334374Clostridium pasteurianum BC1, complete genome6e-100373BLASTN svgBLASTP svg
NC_021182:29653952965395298850023106Clostridium pasteurianum BC1, complete genome5e-79303BLASTN svgBLASTP svg
NC_010723:22318342231834225453622703Clostridium botulinum E3 str. Alaska E43, complete genome8e-50206BLASTN svgBLASTP svg
NC_010674:24352412435241245936424124Clostridium botulinum B str. Eklund 17B, complete genome1e-48202BLASTN svgBLASTP svg
NC_013316:1*14895548955Clostridium difficile R20291, complete genome2e-1695.6BLASTN svgBLASTP svg
NC_009089:1*13459934599Clostridium difficile 630, complete genome2e-1695.6BLASTN svgBLASTP svg
NC_019978:39000*390005838419385Halobacteroides halobius DSM 5150, complete genome9e-1693.7BLASTN svgBLASTP svg
NC_008262:2348328*2348328236708418757Clostridium perfringens SM101, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_003454:20807052080705210460123897Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete1e-1489.7BLASTN svgBLASTP svg
NC_013515:347671*34767139636648696Streptobacillus moniliformis DSM 12112, complete genome8e-1383.8BLASTN svgBLASTP svg
NC_003454:618290*61829063831520026Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete5e-1177.8BLASTN svgBLASTP svg
NC_014328:23269302326930235084023911Clostridium ljungdahlii ATCC 49587 chromosome, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_004557:32094*320945657224479Clostridium tetani E88, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_003228:36905963690596371414723552Bacteroides fragilis NCTC 9343, complete genome8e-1073.8BLASTN svgBLASTP svg
NC_006347:37604473760447380544144995Bacteroides fragilis YCH46, complete genome8e-1073.8BLASTN svgBLASTP svg
NC_009922:1*12276322763Alkaliphilus oremlandii OhILAs, complete genome8e-1073.8BLASTN svgBLASTP svg
NC_014393:2771774*2771774280609934326Clostridium cellulovorans 743B chromosome, complete genome8e-1073.8BLASTN svgBLASTP svg
NC_014720:417041703476030591Caldicellulosiruptor kronotskyensis 2002 chromosome, complete8e-1073.8BLASTN svgBLASTP svg
NC_010001:1*12082320823Clostridium phytofermentans ISDg, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_014393:1*11925119251Clostridium cellulovorans 743B chromosome, complete genome5e-0867.9BLASTN svgBLASTP svg
NC_008593:2527064*2527064255549928436Clostridium novyi NT, complete genome5e-0867.9BLASTN svgBLASTP svg
NC_010674:1*12076220762Clostridium botulinum B str. Eklund 17B, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_020299:764526*76452681749952974Candidatus Kinetoplastibacterium oncopeltii TCC290E, complete2e-0765.9BLASTN svgBLASTP svg
NC_019949:601691*60169162049118801Mycoplasma cynos C142 complete genome8e-0763.9BLASTN svgBLASTP svg
NC_010723:1*11759917599Clostridium botulinum E3 str. Alaska E43, complete genome8e-0763.9BLASTN svgBLASTP svg
NC_018664:1*12406624066Clostridium acidurici 9a chromosome, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_014328:1*11850018500Clostridium ljungdahlii ATCC 49587 chromosome, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_008261:1*12066720667Clostridium perfringens ATCC 13124, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_003366:112067020670Clostridium perfringens str. 13, complete genome3e-0661.9BLASTN svgBLASTP svg