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Query: NC_003366:2286083 Clostridium perfringens str. 13, complete genome

Start: 2286083, End: 2306156, Length: 20074

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_008262:2169262*2169262218972120460Clostridium perfringens SM101, complete genome05223BLASTN svgBLASTP svg
NC_008261:2481500*2481500250521723718Clostridium perfringens ATCC 13124, complete genome02518BLASTN svgBLASTP svg
NC_010723:915697*91569793892123225Clostridium botulinum E3 str. Alaska E43, complete genome0700BLASTN svgBLASTP svg
NC_014393:1782811*1782811180519922389Clostridium cellulovorans 743B chromosome, complete genome3e-123450BLASTN svgBLASTP svg
NC_021182:2219286*2219286224215022865Clostridium pasteurianum BC1, complete genome1e-82315BLASTN svgBLASTP svg
NC_019970:1991944*1991944200962917686Thermoanaerobacterium thermosaccharolyticum M0795, complete genome6e-81309BLASTN svgBLASTP svg
NC_015555:863173*86317388705323881Thermoanaerobacterium xylanolyticum LX-11 chromosome, complete4e-42180BLASTN svgBLASTP svg
NC_011661:1332309*1332309136399631688Dictyoglomus turgidum DSM 6724, complete genome2e-40174BLASTN svgBLASTP svg
NC_013515:550464*55046456909918636Streptobacillus moniliformis DSM 12112, complete genome2e-37165BLASTN svgBLASTP svg
NC_013517:3082279*3082279310209919821Sebaldella termitidis ATCC 33386, complete genome3e-30141BLASTN svgBLASTP svg
NC_012034:802453*80245382393021478Anaerocellum thermophilum DSM 6725, complete genome1e-26129BLASTN svgBLASTP svg
NC_020291:1045058*1045058106857123514Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome7e-25123BLASTN svgBLASTP svg
NC_018677:111500*11150014809936600Candidatus Portiera aleyrodidarum BT-B-HRs chromosome, complete7e-22113BLASTN svgBLASTP svg
NC_015520:330500*33050035081720318Mahella australiensis 50-1 BON chromosome, complete genome1e-20109BLASTN svgBLASTP svg
NC_011126:1430608*1430608145456623959Hydrogenobaculum sp. Y04AAS1, complete genome1e-20109BLASTN svgBLASTP svg
NC_007644:626992*62699269973472743Moorella thermoacetica ATCC 39073, complete genome1e-20109BLASTN svgBLASTP svg
NC_004545:15650*156506959953950Buchnera aphidicola str. Bp (Baizongia pistaciae), complete genome4e-20107BLASTN svgBLASTP svg
NC_013171:1194500*1194500122104426545Anaerococcus prevotii DSM 20548, complete genome7e-19103BLASTN svgBLASTP svg
NC_018643:937486*93748696281825333Alpha proteobacterium HIMB5 chromosome, complete genome3e-18101BLASTN svgBLASTP svg
NC_013316:3056925*3056925307934422420Clostridium difficile R20291, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_009850:1011293*1011293103921027918Arcobacter butzleri RM4018, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_009089:3142976*3142976316557022595Clostridium difficile 630, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_019949:525249*52524956698841740Mycoplasma cynos C142 complete genome2e-1695.6BLASTN svgBLASTP svg
NC_008700:312099*31209934171429616Shewanella amazonensis SB2B, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_014448:487381*48738151116023780Mycoplasma hyorhinis HUB-1 chromosome, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_015185:13521711352171137893326763Desulfurobacterium thermolithotrophum DSM 11699 chromosome,4e-1487.7BLASTN svgBLASTP svg
NC_013192:1993718*1993718201717323456Leptotrichia buccalis DSM 1135, complete genome2e-1385.7BLASTN svgBLASTP svg
NC_015711:8852850*8852850887609923250Myxococcus fulvus HW-1 chromosome, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_015696:47484*474846907921596Francisella sp. TX077308 chromosome, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_014220:1670000*1670000168813518136Syntrophothermus lipocalidus DSM 12680 chromosome, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_014150:1006000*1006000102850522506Brachyspira murdochii DSM 12563 chromosome, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_015682:379373*37937340238523013Thermodesulfobacterium sp. OPB45 chromosome, complete genome2e-0971.9BLASTN svgBLASTP svg
NC_015587:1414304*1414304143487820575Hydrogenobaculum sp. SHO chromosome, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_015557:1412917*1412917143685823942Hydrogenobaculum sp. 3684 chromosome, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_015318:249445*24944527619526751Hippea maritima DSM 10411 chromosome, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_010003:335348*33534835377918432Petrotoga mobilis SJ95, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_010424:531727*53172755409922373Candidatus Desulforudis audaxviator MP104C, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_012968:2228943*2228943225222323281Methylotenera mobilis JLW8, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_014654:18883518883520899520161Halanaerobium sp. 'sapolanicus' chromosome, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_011653:1616423*1616423164434727925Thermosipho africanus TCF52B, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_019977:1621939*1621939164769225754Methanomethylovorans hollandica DSM 15978, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_007519:1782067*1782067181840436338Desulfovibrio alaskensis G20 chromosome, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_007168:45400045400047628822289Staphylococcus haemolyticus JCSC1435, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_015380:859424*85942488083621413Candidatus Pelagibacter sp. IMCC9063 chromosome, complete genome9e-0660BLASTN svgBLASTP svg
NC_014253:312354*31235434601333660Methanohalobium evestigatum Z-7303 chromosome, complete genome9e-0660BLASTN svgBLASTP svg
NC_007907:34724943472494349615323660Desulfitobacterium hafniense Y51, complete genome9e-0660BLASTN svgBLASTP svg