Pre_GI: BLASTN Hits

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Query: NC_003366:1122654 Clostridium perfringens str. 13, complete genome

Start: 1122654, End: 1140599, Length: 17946

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_008261:13328641332864135143618573Clostridium perfringens ATCC 13124, complete genome010850BLASTN svgBLASTP svg
NC_008262:11395001139500116059921100Clostridium perfringens SM101, complete genome010570BLASTN svgBLASTP svg
NC_010674:21857042185704221026824565Clostridium botulinum B str. Eklund 17B, complete genome01316BLASTN svgBLASTP svg
NC_010723:20827502082750210459921850Clostridium botulinum E3 str. Alaska E43, complete genome01251BLASTN svgBLASTP svg
NC_014538:985339985339100713721799Thermoanaerobacter sp. X513 chromosome, complete genome1e-1799.6BLASTN svgBLASTP svg
NC_019970:20804192080419209909918681Thermoanaerobacterium thermosaccharolyticum M0795, complete genome4e-1797.6BLASTN svgBLASTP svg
NC_013517:1055854*10558541161670105817Sebaldella termitidis ATCC 33386, complete genome4e-1177.8BLASTN svgBLASTP svg
NC_007482:60736560736563471527351Pseudoalteromonas haloplanktis TAC125 chromosome II, complete6e-1073.8BLASTN svgBLASTP svg
NC_009454:48995448995451152821575Pelotomaculum thermopropionicum SI, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_014654:11131161113116113933826223Halanaerobium sp. 'sapolanicus' chromosome, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_014964:55791055791057776519856Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, complete9e-0969.9BLASTN svgBLASTP svg
NC_010677:214712*21471224609931388Francisella tularensis subsp. mediasiatica FSC147, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_008245:141982*14198217415532174Francisella tularensis subsp. tularensis FSC 198, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_006570:141966*14196617413932174Francisella tularensis subsp. tularensis Schu 4, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_010336:1117325*1117325114783030506Francisella philomiragia subsp. philomiragia ATCC 25017, complete2e-0661.9BLASTN svgBLASTP svg
NC_009648:38036223803622385072747106Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genome8e-0660BLASTN svgBLASTP svg