Pre_GI: BLASTP Hits

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Query: NC_003366:981105:998264 Clostridium perfringens str. 13, complete genome

Start: 998264, End: 998752, Length: 489

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:904000:925034925034925471438Clostridium perfringens SM101, complete genomeacetyltransferase, GNAT family2e-64244
NC_002516:1474000:149495914949591495492534Pseudomonas aeruginosa PAO1, complete genomehypothetical protein1e-1685.5
NC_020418:1841138:184295518429551843458504Morganella morganii subsp. morganii KT, complete genomeAcetyltransferase (GNAT) family protein2e-1581.3
NC_007005:2686551:272794827279482728475528Pseudomonas syringae pv. syringae B728a, complete genomeGCN5-related N-acetyltransferase1e-1375.9
NC_006510:2910000:291004129100412910595555Geobacillus kaustophilus HTA426, complete genomehypothetical protein1e-1272.4
NC_014923:1249267:126575012657501266280531Mesorhizobium ciceri biovar biserrulae WSM1271 chromosome, completeGCN5-related N-acetyltransferase3e-1270.9
NC_018665:2163713:217286421728642173352489Exiguobacterium antarcticum B7 chromosome, complete genomeGCN5-related N-acetyltransferase5e-1270.5
NC_010556:2328303:233468723346872335196510Exiguobacterium sibiricum 255-15, complete genomeGCN5-related N-acetyltransferase6e-1270.1
NC_009328:2905000:290605929060592906733675Geobacillus thermodenitrificans NG80-2 chromosome, complete genomehypothetical protein2e-1065.1
NC_020291:795500:801111801111801608498Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeGCN5-related N-acetyltransferase1e-0962.8
NC_015930:821342:840086840086840574489Lactococcus garvieae ATCC 49156, complete genomeacetyltransferase2e-0961.6
NC_003454:677699:692298692298692804507Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeRibosomal-protein-alanine acetyltransferase2e-0961.2
NC_010516:3545017:354782935478293548362534Clostridium botulinum B1 str. Okra, complete genomeacetyltransferase, GNAT family1e-0859.3
NC_018664:2638102:265167326516732652221549Clostridium acidurici 9a chromosome, complete genomeacetyltransferase, GNAT family9e-0959.3
NC_006322:1959918:196724719672471967765519Bacillus licheniformis ATCC 14580, complete genomehypothetical protein2e-0858.5
NC_015391:2523451:252989925298992530399501Carnobacterium sp. 17-4 chromosome, complete genomeputative N-acetyltransferase, GNAT family3e-0857.8
NC_015500:900807:913193913193913717525Treponema brennaborense DSM 12168 chromosome, complete genomeGCN5-related N-acetyltransferase3e-0857.8
NC_021175:1291707:130909613090961309617522Streptococcus oligofermentans AS 1.3089, complete genomehypothetical protein4e-0857.4
NC_013315:1230214:124969312496931250139447Clostridium difficile CD196 chromosome, complete genomeacetyltransferase7e-0856.6
NC_013316:1225797:124731012473101247756447Clostridium difficile R20291, complete genomeputative acetyltransferase7e-0856.6
NC_019970:1457794:146708914670891467640552Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeacetyltransferase, ribosomal protein N-acetylase1e-0755.8
NC_014410:1527405:153164115316411532192552Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,GCN5-related N-acetyltransferase1e-0755.8
NC_008262:2348328:236343823634382363884447Clostridium perfringens SM101, complete genomeribosomal-protein-alanine acetyltransferase2e-0755.5
NC_016791:3891272:390238039023803902874495Clostridium sp. BNL1100 chromosome, complete genomesortase2e-0755.1
NC_004603:1897532:190564119056411906186546Vibrio parahaemolyticus RIMD 2210633 chromosome I, completehypothetical protein2e-0755.1
NC_012580:301500:318250318250318771522Vibrio cholerae M66-2 chromosome II, complete sequenceN-acetyltransferase GCN53e-0754.7
NC_002506:370629:394041394041394556516Vibrio cholerae O1 biovar eltor str. N16961 chromosome II, completeacetyltransferase, putative2e-0754.7
NC_009456:787322:858099858099858614516Vibrio cholerae O395 chromosome 1, complete sequenceputative acetyltransferase2e-0754.7
NC_012583:361241:405328405328405843516Vibrio cholerae O395 chromosome chromosome II, complete sequenceGCN5-related N-acetyltransferase2e-0754.7
NC_016945:370471:393860393860394375516Vibrio cholerae IEC224 chromosome II, complete sequenceN-acetyltransferase GCN53e-0754.3
NC_017269:303500:330472330472330987516Vibrio cholerae LMA3984-4 chromosome II, complete sequenceacetyltransferase5e-0753.9
NC_016945:370471:433607433607434122516Vibrio cholerae IEC224 chromosome II, complete sequencehypothetical protein5e-0753.9
NC_002506:370629:433710433710434303594Vibrio cholerae O1 biovar eltor str. N16961 chromosome II, completeacetyltransferase, putative5e-0753.5
NC_009456:787322:800942800942801535594Vibrio cholerae O395 chromosome 1, complete sequenceputative acetyltransferase5e-0753.5
NC_016446:119914:134251134251134844594Vibrio cholerae O1 str. 2010EL-1786 chromosome 2, completehypothetical protein5e-0753.5
NC_012583:440420:462479462479463000522Vibrio cholerae O395 chromosome chromosome II, complete sequenceGCN5-related N-acetyltransferase5e-0753.5
NC_015555:1450704:145399514539951454558564Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeGCN5-related N-acetyltransferase6e-0753.1
NC_016791:3953972:398019839801983980692495Clostridium sp. BNL1100 chromosome, complete genomesortase9e-0752.8
NC_016751:1604048:162075316207531621283531Marinitoga piezophila KA3 chromosome, complete genomeacetyltransferase, ribosomal protein N-acetylase9e-0752.8
NC_019970:2190695:219472721947272195173447Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeribosomal-protein-alanine acetyltransferase1e-0652.4
NC_014376:693820:698755698755699189435Clostridium saccharolyticum WM1 chromosome, complete genomeribosomal-protein-alanine acetyltransferase1e-0652.4
NC_014410:2149886:215091121509112151357447Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,ribosomal-protein-alanine acetyltransferase1e-0652.4
NC_010694:1052722:105699810569981057564567Erwinia tasmaniensis, complete genomeSpermidine N1-acetyltransferase1e-0652
NC_014150:233194:251673251673252173501Brachyspira murdochii DSM 12563 chromosome, complete genomeGCN5-related N-acetyltransferase1e-0652
NC_013456:1743046:176108317610831761628546Vibrio sp. Ex25 chromosome 1, complete genomehypothetical protein2e-0652
NC_013406:2207520:221452822145282215067540Paenibacillus sp. Y412MC10 chromosome, complete genomeGCN5-like N-acetyltransferase2e-0651.6
NC_014330:2409559:241052424105242410976453Brachyspira pilosicoli 95/1000 chromosome, complete genomeribosomal-protein-alanine acetyltransferase2e-0651.6
NC_014377:1897857:190160119016011902071471Thermosediminibacter oceani DSM 16646 chromosome, complete genome(SSU ribosomal protein S18P)-alanine acetyltransferase3e-0651.2
NC_019908:852230:869161869161869658498Brachyspira pilosicoli P43/6/78 chromosome, complete genomeribosomal-protein-alanine acetyltransferase3e-0650.8
NC_015555:693461:714974714974715420447Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeribosomal-protein-alanine acetyltransferase4e-0650.4
NC_004193:375416:481532481532482041510Oceanobacillus iheyensis HTE831, complete genomephosphinothricin N-acetyltransferase6e-0650.1
NC_015958:1465631:146980414698041470373570Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeGCN5-like N-acetyltransferase1e-0549.3