Pre_GI: BLASTP Hits

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Query: NC_003366:981105:993161 Clostridium perfringens str. 13, complete genome

Start: 993161, End: 993781, Length: 621

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:904000:919919919919920539621Clostridium perfringens SM101, complete genomehypothetical protein8e-95346
NC_015519:426948:427793427793428374582Tepidanaerobacter sp. Re1 chromosome, complete genomehypothetical protein5e-31134
NC_011898:2951670:297338729733872974157771Clostridium cellulolyticum H10, complete genomeprotein of unknown function DUF2184e-29127
NC_008618:1206157:122090612209061221658753Bifidobacterium adolescentis ATCC 15703, complete genomehypothetical protein3e-28125
NC_013714:1521404:153780115378011538427627Bifidobacterium dentium Bd1, complete genomehypothetical protein8e-28123
NC_013316:2033906:203736120373612038107747Clostridium difficile R20291, complete genomehypothetical protein3e-26118
NC_009922:2323083:233865723386572339232576Alkaliphilus oremlandii OhILAs, complete genomeprotein of unknown function DUF2183e-24111
NC_017353:646195:6461956461956471991005Staphylococcus lugdunensis N920143, complete genomeputative lantibiotic resistance protein4e-24110
NC_013204:74855:9231892318933191002Eggerthella lenta DSM 2243, complete genomeprotein of unknown function DUF2182e-23109
NC_018720:417500:4306074306074316891083Bifidobacterium asteroides PRL2011 chromosome, complete genomehypothetical protein4e-22104
NC_015737:2691246:273595527359552736701747Clostridium sp. SY8519, complete genomehypothetical protein7e-22103
NC_017294:1096000:110045111004511100999549Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomemembrane protein1e-21102
NC_015913:1117500:112210211221021122650549Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomehypothetical protein1e-21102
NC_016012:1010405:101752610175261018074549Candidatus Arthromitus sp. SFB-rat-Yit, complete genomemembrane protein3e-21101
NC_003366:1427785:144903014490301449803774Clostridium perfringens str. 13, complete genomehypothetical protein1e-2099.8
NC_018750:3661243:3680081368008136811031023Streptomyces venezuelae ATCC 10712, complete genomehypothetical protein3e-2098.2
NC_004557:2078000:209394320939432094521579Clostridium tetani E88, complete genomemembrane associated protein4e-2097.8
NC_016641:4290350:430648543064854307180696Paenibacillus terrae HPL-003 chromosome, complete genomehypothetical protein9e-1993.6
NC_010320:671699:671699671699672277579Thermoanaerobacter sp. X514 chromosome, complete genomehypothetical protein3e-1891.7
NC_015683:2279904:2285743228574322867681026Corynebacterium ulcerans BR-AD22 chromosome, complete genomehypothetical protein8e-1787
NC_013093:3768790:3774980377498037759901011Actinosynnema mirum DSM 43827, complete genomeprotein of unknown function DUF2188e-1787
NC_017317:2181284:2186457218645721874821026Corynebacterium ulcerans 809 chromosome, complete genomehypothetical protein1e-1686.3
NC_013714:570329:5839885839885850281041Bifidobacterium dentium Bd1, complete genomehypothetical protein1e-1685.9
NC_007969:2885249:291607429160742916853780Psychrobacter cryohalolentis K5, complete genomeprotein of unknown function DUF2182e-1479.3
NC_013406:7024149:704294670429467043530585Paenibacillus sp. Y412MC10 chromosome, complete genomehypothetical protein3e-1478.2
NC_020207:843822:8689528689528701511200Enterococcus faecium NRRL B-2354, complete genomehypothetical protein6e-1477.4
NC_010376:186510:231558231558232484927Finegoldia magna ATCC 29328, complete genomehypothetical protein3e-1375.1
NC_015687:389500:406786406786407463678Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein3e-1375.1
NC_003030:389500:406790406790407467678Clostridium acetobutylicum ATCC 824, complete genomeUncharacterized conserved membrane protein, SANA family3e-1375.1
NC_017295:389500:406780406780407457678Clostridium acetobutylicum EA 2018 chromosome, complete genomehypothetical protein3e-1375.1
NC_014168:994640:99966599966510006991035Segniliparus rotundus DSM 44985 chromosome, complete genomehypothetical protein8e-1270.5
NC_010718:2265447:229395322939532294537585Natranaerobius thermophilus JW/NM-WN-LF, complete genomeprotein of unknown function DUF2183e-1168.2
NC_011035:1908000:193008119300811930737657Neisseria gonorrhoeae NCCP11945 chromosome, complete genomePeriplasmic protein8e-1063.9
NC_017511:1812000:183392418339241834580657Neisseria gonorrhoeae TCDC-NG08107 chromosome, complete genomehypothetical protein8e-1063.9
NC_014828:1905479:191433719143371915113777Ethanoligenens harbinense YUAN-3 chromosome, complete genomeprotein of unknown function DUF2187e-1063.9
NC_016887:1714664:171537617153761715996621Nocardia cyriacigeorgica GUH-2, complete genomehypothetical protein9e-1063.5
NC_006361:3615322:363550836355083636455948Nocardia farcinica IFM 10152, complete genomehypothetical protein1e-0963.2
NC_015275:3846260:386769438676943868395702Clostridium lentocellum DSM 5427 chromosome, complete genomeprotein of unknown function DUF2181e-0963.2
NC_014758:245707:255619255619256335717Calditerrivibrio nitroreducens DSM 19672 chromosome, completehypothetical protein1e-0860.1
NC_014507:906960:909532909532910080549Methanoplanus petrolearius DSM 11571 chromosome, complete genomehypothetical protein2e-0858.9
NC_013947:4979000:498271749827174983394678Stackebrandtia nassauensis DSM 44728 chromosome, complete genomehypothetical protein1e-0756.6
NC_011725:2949519:296654729665472967179633Bacillus cereus B4264 chromosome, complete genomehypothetical protein3e-0755.1
NC_017265:1571305:1571305157130515724321128Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein1e-0653.5
NC_003143:2804500:2820818282081828219451128Yersinia pestis CO92, complete genomehypothetical protein1e-0653.5
NC_006155:2979500:3014057301405730151841128Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein1e-0653.5
NC_010634:2894631:2931998293199829331251128Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein1e-0653.5
NC_010159:1818500:1834856183485618359831128Yersinia pestis Angola, complete genomehypothetical protein1e-0653.5
NC_008149:2366500:2382602238260223837291128Yersinia pestis Nepal516, complete genomehypothetical protein1e-0653.5
NC_005810:2549680:2586872258687225879991128Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein1e-0653.5
NC_009381:2138625:2173026217302621741531128Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein1e-0653.5
NC_009708:1735903:1737907173790717390341128Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein1e-0653.5
NC_014029:2756500:2773141277314127742681128Yersinia pestis Z176003 chromosome, complete genomehypothetical protein1e-0653.5
NC_017154:2804000:2820291282029128214181128Yersinia pestis D106004 chromosome, complete genomehypothetical protein1e-0653.5
NC_017160:2787637:2787637278763727887641128Yersinia pestis D182038 chromosome, complete genomehypothetical protein1e-0653.5
NC_013456:1743046:175612017561201756737618Vibrio sp. Ex25 chromosome 1, complete genomehypothetical protein1e-0652.8