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Query: NC_003366:981105:990191 Clostridium perfringens str. 13, complete genome

Start: 990191, End: 991474, Length: 1284

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:904000:9168959168959181781284Clostridium perfringens SM101, complete genomehypothetical protein0689
NC_018515:4196409:4206266420626642075731308Desulfosporosinus meridiei DSM 13257 chromosome, complete genomehypothetical protein2e-71269
NC_015311:365007:3802283802283815171290Prevotella denticola F0289 chromosome, complete genomehypothetical protein1e-68260
NC_014933:3942156:3962382396238239636651284Bacteroides helcogenes P 36-108 chromosome, complete genomeinner membrane protein7e-66251
NC_014364:2904443:2907783290778329090841302Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeprotein of unknown function DUF10631e-61237
NC_009089:3782000:3783072378307237843551284Clostridium difficile 630, complete genomehypothetical protein2e-59230
NC_014618:586240:6143916143916157011311Enterobacter cloacae SCF1 chromosome, complete genomehypothetical protein3e-59229
NC_009495:2085000:2094992209499220962841293Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein7e-59228
NC_009697:2012500:2023633202363320249251293Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein7e-59228
NC_009698:2012500:2023850202385020251421293Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein7e-59228
NC_017297:2143000:2153431215343121547231293Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein3e-58226
NC_009699:2142177:2153332215333221546241293Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein3e-58226
NC_010516:2093901:2103098210309821043901293Clostridium botulinum B1 str. Okra, complete genomehypothetical protein3e-58226
NC_012779:2957000:2971262297126229725571296Edwardsiella ictaluri 93-146, complete genomehypothetical protein1e-57224
NC_012563:2230403:2241701224170122429901290Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-57224
NC_012658:2138791:2149723214972321510121290Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein2e-57223
NC_018870:2479114:2486924248692424882431320Thermacetogenium phaeum DSM 12270 chromosome, complete genomeserine dehydratase-like, subunit alpha5e-55215
NC_013941:3884725:3884725388472538860351311Escherichia coli O55:H7 str. CB9615 chromosome, complete genomehypothetical protein7e-55214
NC_002695:3994970:3994970399497039962801311Escherichia coli O157:H7 str. Sakai, complete genomehypothetical protein7e-55214
NC_011415:3523364:3523364352336435246741311Escherichia coli SE11 chromosome, complete genomehypothetical protein8e-55214
NC_012947:630757:6508556508556521651311Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completehypothetical protein9e-55214
NC_011750:3768692:3768692376869237700021311Escherichia coli IAI39 chromosome, complete genomehypothetical protein9e-55214
NC_011751:3710786:3710786371078637120961311Escherichia coli UMN026 chromosome, complete genomehypothetical protein2e-54213
NC_021066:3703725:3711465371146537127751311Raoultella ornithinolytica B6, complete genomehypothetical protein3e-54212
CU928145:3608917:3608917360891736102271311Escherichia coli 55989 chromosome, complete genomeconserved hypothetical protein3e-54212
NC_011748:3608917:3608917360891736102271311Escherichia coli 55989, complete genomehypothetical protein3e-54212
NC_010658:3014371:3031259303125930325691311Shigella boydii CDC 3083-94, complete genomehypothetical protein3e-53209
NC_016048:4163225:4166769416676941680461278Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein1e-48194
NC_015873:380485:4054994054994068181320Megasphaera elsdenii DSM 20460, complete genomeUPF0597 protein HMPREF0889_14063e-48193
NC_016630:1610723:1621430162143016226651236Filifactor alocis ATCC 35896 chromosome, complete genomeinner membrane protein9e-48191
NC_016077:2044876:2048537204853720498771341Acidaminococcus intestini RyC-MR95 chromosome, complete genomehypothetical protein3e-47189
NC_015500:159199:1626371626371639261290Treponema brennaborense DSM 12168 chromosome, complete genomeUPF0597 protein yhaM1e-42174
NC_012785:638000:6431456431456444131269Kosmotoga olearia TBF 19.5.1, complete genomeprotein of unknown function DUF10635e-39162