Pre_GI: BLASTP Hits

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Query: NC_003366:981105:985047 Clostridium perfringens str. 13, complete genome

Start: 985047, End: 985406, Length: 360

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004463:5540924:555390755539075554608702Bradyrhizobium japonicum USDA 110, complete genomehypothetical protein2e-0857.8
NC_017161:1:123251232512990666Hydrogenobacter thermophilus TK-6 chromosome, complete genomehypothetical protein9e-0958.9
NC_016642:757964:761247761247761987741Pseudovibrio sp. FO-BEG1 chromosome, complete genomehypothetical protein1e-0755.1
NC_015161:1556766:158660715866071587332726Deinococcus proteolyticus MRP chromosome, complete genomehypothetical protein7e-0752.8
NC_009524:1369395:136863413686341369398765Psychrobacter sp. PRwf-1 chromosome, complete genomehypothetical protein1e-0548.9
NC_009922:2323083:233260823326082333318711Alkaliphilus oremlandii OhILAs, complete genomeprotein of unknown function DUF451e-1065.5
NC_014209:1363151:138894013889401389614675Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,protein of unknown function DUF454e-0753.5
NC_018876:2151226:215688321568832157608726Methanolobus psychrophilus R15 chromosome, complete genomeprotein of unknown function DUF451e-0858.9
NC_015275:3243689:325730332573033257995693Clostridium lentocellum DSM 5427 chromosome, complete genomeprotein of unknown function DUF454e-0753.5
NC_012881:1802000:181666418166641817356693Desulfovibrio salexigens DSM 2638, complete genomeprotein of unknown function DUF452e-0651.2
NC_010003:1126800:113860011386001139271672Petrotoga mobilis SJ95, complete genomeprotein of unknown function DUF452e-0754.3
NC_021184:3259908:327702332770233277727705Desulfotomaculum gibsoniae DSM 7213, complete genomeputative metal-dependent hydrolase2e-0650.8
NC_013799:1:122641226412929666Hydrogenobacter thermophilus TK-6, complete genomeputative metal-dependent hydrolase9e-0958.9
NC_016047:2480921:248716224871622487836675Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completezinc metalloprotease1e-0651.6