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Query: NC_003366:981105:982027 Clostridium perfringens str. 13, complete genome

Start: 982027, End: 983271, Length: 1245

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018664:239000:2560362560362572771242Clostridium acidurici 9a chromosome, complete genomeflagellin lysine-N-methylase FliB2e-60233
NC_008262:904000:911480911480911824345Clostridium perfringens SM101, complete genomeFliB domain protein2e-59229
NC_014098:3030274:3046234304623430474871254Bacillus tusciae DSM 2912 chromosome, complete genomehypothetical protein6e-56218
NC_016631:297222:3220203220203233001281Granulicella mallensis MP5ACTX8 chromosome, complete genomehypothetical protein1e-35150
NC_019897:128610:1825611825611838141254Thermobacillus composti KWC4 chromosome, complete genomehypothetical protein2e-31136
NC_015424:1603000:1622142162214216233321191Aeromonas veronii B565 chromosome, complete genomeFliU-like protein1e-25117
NC_004347:4302768:4333899433389943350771179Shewanella oneidensis MR-1, complete genomeflagellar biosynthesis protein, putative2e-22107
NC_015565:1920329:1937803193780319390501248Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completehypothetical protein9e-21101
NC_015589:1240197:1258098125809812593211224Desulfotomaculum ruminis DSM 2154 chromosome, complete genomehypothetical protein2e-20100
NC_008800:2695977:2714907271490727161121206Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,flagellin lysine-N-methylase2e-1997.1
NC_015224:2017781:2037669203766920388741206Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,flagellin lysine-N-methylase2e-1997.1
NC_015275:3299923:3300414330041433015951182Clostridium lentocellum DSM 5427 chromosome, complete genomeflagellin lysine-N-methylase5e-1995.9
NC_015711:3193774:3197071319707131983511281Myxococcus fulvus HW-1 chromosome, complete genomeFliB family protein3e-1893.6