Pre_GI: BLASTP Hits

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Query: NC_003366:863437:878020 Clostridium perfringens str. 13, complete genome

Start: 878020, End: 878352, Length: 333

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008261:817295:834077834077834409333Clostridium perfringens ATCC 13124, complete genometranscriptional regulator, PadR family2e-54210
NC_012673:785718:792796792796793152357Exiguobacterium sp. AT1b, complete genometranscriptional regulator, PadR-like family1e-30131
NC_014393:4352216:437518143751814375525345Clostridium cellulovorans 743B chromosome, complete genometranscriptional regulator, PadR-like family3e-28124
NC_014393:4612301:463298446329844633328345Clostridium cellulovorans 743B chromosome, complete genometranscriptional regulator, PadR-like family5e-28122
NC_014328:3747973:375165537516553751996342Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative PadR family transcriptional regulator2e-25114
NC_004193:375416:420145420145420480336Oceanobacillus iheyensis HTE831, complete genomehypothetical protein2e-21101
NC_014330:1010000:101901510190151019344330Brachyspira pilosicoli 95/1000 chromosome, complete genomeputative transcriptional regulator3e-2097.4
NC_019897:700332:733396733396733758363Thermobacillus composti KWC4 chromosome, complete genometranscriptional regulator3e-2097.4
NC_019908:2183215:219799821979982198327330Brachyspira pilosicoli P43/6/78 chromosome, complete genometranscriptional regulator4e-2096.7
NC_015589:814530:827671827671828009339Desulfotomaculum ruminis DSM 2154 chromosome, complete genometranscriptional regulator PadR family protein3e-1993.6
NC_016935:789849:805610805610805939330Paenibacillus mucilaginosus 3016 chromosome, complete genomePadR-like family transcriptional regulator4e-1993.2
NC_015690:790500:804304804304804633330Paenibacillus mucilaginosus KNP414 chromosome, complete genomePadR-like family transcriptional regulator4e-1993.2
NC_008278:2813362:282291428229142823243330Frankia alni ACN14a, complete genomePutative PadR family transcriptional regulator7e-1992.4
NC_015690:6595395:660345166034516603786336Paenibacillus mucilaginosus KNP414 chromosome, complete genomePadR-like family transcriptional regulator3e-1890.5
NC_018664:2638102:264078026407802641118339Clostridium acidurici 9a chromosome, complete genometranscriptional regulator, PadR family4e-1683.2
NC_012778:364728:368015368015368353339Eubacterium eligens ATCC 27750, complete genomehypothetical protein5e-1683.2
NC_004722:1008500:101926110192611019602342Bacillus cereus ATCC 14579, complete genomeTranscriptional regulator, PadR family7e-1579.3
NC_011725:1032500:104332810433281043660333Bacillus cereus B4264 chromosome, complete genomePadR family transcriptional regulator6e-1579.3
NC_017208:1050414:106205310620531062385333Bacillus thuringiensis serovar chinensis CT-43 chromosome, completePadR family transcriptional regulator6e-1579.3
NC_014171:1018338:102901910290191029351333Bacillus thuringiensis BMB171 chromosome, complete genomePadR family transcriptional regulator1e-1478.6
NC_010184:1017000:102748510274851027817333Bacillus weihenstephanensis KBAB4, complete genometranscriptional regulator, PadR-like family2e-1477.8
NC_011830:1037520:105271710527171053064348Desulfitobacterium hafniense DCB-2, complete genometranscriptional regulator, PadR-like family2e-1477.4
NC_007907:4956500:496671849667184967065348Desulfitobacterium hafniense Y51, complete genomehypothetical protein3e-1477.4
NC_009464:931647:932620932620932970351Uncultured methanogenic archaeon RC-I, complete genomeputative transcription regulator (PadR family)1e-1272
NC_012483:996555:101723810172381017600363Acidobacterium capsulatum ATCC 51196, complete genometranscriptional regulator, PadR family1e-1272
NC_013665:1766158:179097717909771791321345Methanocella paludicola SANAE, complete genomeputative PadR-like family transcriptional regulator2e-1271.2
NC_015690:2039215:204633620463362046665330Paenibacillus mucilaginosus KNP414 chromosome, complete genomePadR-like family transcriptional regulator8e-1268.9
NC_014323:3976351:401955840195584019887330Herbaspirillum seropedicae SmR1 chromosome, complete genometranscription regulator protein1e-1168.6
NC_013730:4573077:459200745920074592351345Spirosoma linguale DSM 74, complete genometranscriptional regulator, PadR-like family1e-1168.6
NC_015275:1480500:149883014988301499192363Clostridium lentocellum DSM 5427 chromosome, complete genometranscriptional regulator, PadR-like family1e-1168.2
NC_007644:2452244:246911124691112469470360Moorella thermoacetica ATCC 39073, complete genometranscriptional regulator, PadR-like family4e-1167
NC_015434:228912:250216250216250554339Verrucosispora maris AB-18-032 chromosome, complete genomePadR-like family transcriptional regulator3e-1063.5
NC_005957:4472800:447576544757654476109345Bacillus thuringiensis serovar konkukian str. 97-27, completepossible transcriptional regulator, PadR family1e-0961.6
NC_009328:293000:348394348394348717324Geobacillus thermodenitrificans NG80-2 chromosome, complete genometranscriptional regulator2e-0961.2
NC_014335:4414052:441474244147424415086345Bacillus cereus biovar anthracis str. CI chromosome, completeputative PadR family transcriptional regulator2e-0960.8
NC_013406:1145268:114943211494321149938507Paenibacillus sp. Y412MC10 chromosome, complete genomePadR-like family transcriptional regulator3e-0960.5
NC_010184:4497473:450447345044734504817345Bacillus weihenstephanensis KBAB4, complete genometranscriptional regulator, PadR-like family3e-0960.5
NC_015500:2417041:242087724208772421203327Treponema brennaborense DSM 12168 chromosome, complete genometranscriptional regulator, PadR-like family1e-0858.5
NC_016048:2343500:235035923503592350718360Oscillibacter valericigenes Sjm18-20, complete genomeputative PadR family transcriptional regulator1e-0858.2
NC_014624:828943:843139843139843462324Eubacterium limosum KIST612 chromosome, complete genometranscription regulator (putative)2e-0858.2
NC_006348:2738425:275557927555792755920342Burkholderia mallei ATCC 23344 chromosome 1, complete sequencetranscriptional regulator, PadR family2e-0857.8
NC_003888:3111998:311595731159573116334378Streptomyces coelicolor A3(2), complete genomehypothetical protein3e-0857.4
NC_009712:334143:337653337653337979327Candidatus Methanoregula boonei 6A8, complete genomePadR-like family transcriptional regulator3e-0857.4
NC_016935:1636278:169910916991091699438330Paenibacillus mucilaginosus 3016 chromosome, complete genomePadR family transcriptional regulator5e-0856.6
NC_013729:6217500:622935962293596230051693Kribbella flavida DSM 17836, complete genometranscriptional regulator, PadR-like family4e-0856.6
NC_012914:5194791:520760352076035207929327Paenibacillus sp. JDR-2, complete genometranscriptional regulator, PadR-like family6e-0856.2
NC_009033:755226:756710756710757102393Staphylothermus marinus F1, complete genometranscriptional regulator, PadR-like family6e-0856.2
NC_014210:3817948:382363438236343824467834Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 chromosome,transcriptional regulator, PadR-like family6e-0856.2
NC_008009:2430509:244906824490682449397330Acidobacteria bacterium Ellin345, complete genometranscriptional regulator, PadR-like family8e-0855.8
NC_013037:6209424:621816562181656218518354Dyadobacter fermentans DSM 18053, complete genometranscriptional regulator, PadR-like family1e-0755.1
NC_014963:4416339:442588144258814426225345Terriglobus saanensis SP1PR4 chromosome, complete genomePadR family transcriptional regulator2e-0754.3
NC_013739:2057781:207558820755882075941354Conexibacter woesei DSM 14684, complete genometranscriptional regulator, PadR-like family3e-0753.9
NC_016935:2567039:259505025950502595394345Paenibacillus mucilaginosus 3016 chromosome, complete genomePadR-like family transcriptional regulator4e-0753.5
NC_013730:2751484:278794927879492788323375Spirosoma linguale DSM 74, complete genometranscriptional regulator, PadR-like family7e-0752.8
NC_017059:1727095:173115517311551731733579Rhodospirillum photometricum DSM 122, complete genomePadR family transcriptional regulator8e-0752.4
NC_011773:4541306:454435645443564544616261Bacillus cereus AH820 chromosome, complete genomePadR family transcriptional regulator1e-0651.6
NC_017317:2149794:217301021730102173384375Corynebacterium ulcerans 809 chromosome, complete genomePadR-family transcription regulator2e-0651.2
NC_015474:72103:752397523975691453Pyrococcus sp. NA2 chromosome, complete genomeTranscription regulator, PadR-like family2e-0651.2
NC_004193:375416:597160597160597489330Oceanobacillus iheyensis HTE831, complete genomehypothetical protein2e-0650.8
NC_015683:2249949:227154922715492271923375Corynebacterium ulcerans BR-AD22 chromosome, complete genomePadR family transcription regulator3e-0650.8
NC_014963:4091910:410257441025744102915342Terriglobus saanensis SP1PR4 chromosome, complete genomePadR family transcriptional regulator3e-0650.8
NC_013665:1865122:187697718769771877318342Methanocella paludicola SANAE, complete genomeputative PadR-like family transcriptional regulator3e-0650.4
NC_013891:640784:661436661436661762327Listeria seeligeri serovar 1/2b str. SLCC3954, complete genometranscriptional regulator, PadR family3e-0650.4
NC_014958:3131191:313175231317523132108357Deinococcus maricopensis DSM 21211 chromosome, complete genomePadR family transcriptional regulator3e-0650.4
NC_016023:1419217:143151914315191431875357Bacillus coagulans 36D1 chromosome, complete genomePadR-like family transcriptional regulator3e-0650.4
NC_019908:21970:400324003240364333Brachyspira pilosicoli P43/6/78 chromosome, complete genomehypothetical protein4e-0650.1
NC_018748:495011:494685494685495014330Emticicia oligotrophica DSM 17448 chromosome, complete genometranscriptional regulator, PadR-like family4e-0650.1
NC_014963:4416339:441861944186194418948330Terriglobus saanensis SP1PR4 chromosome, complete genomePadR family transcriptional regulator4e-0650.1
NC_015690:1818333:183487818348781835210333Paenibacillus mucilaginosus KNP414 chromosome, complete genomehypothetical protein5e-0650.1
NC_018704:1424728:142569314256931426040348Amphibacillus xylanus NBRC 15112, complete genomeputative PadR family transcriptional regulator7e-0649.3