Pre_GI: BLASTP Hits

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Query: NC_003366:863437:876855 Clostridium perfringens str. 13, complete genome

Start: 876855, End: 877295, Length: 441

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:784878:815627815627816067441Clostridium perfringens SM101, complete genome3-dehydroquinate dehydratase, type II1e-78291
NC_008261:817295:830540830540830974435Clostridium perfringens ATCC 13124, complete genome3-dehydroquinate dehydratase, type II5e-78288
NC_012034:1783912:178502917850291785466438Anaerocellum thermophilum DSM 6725, complete genome3-dehydroquinate dehydratase, type II8e-51198
NC_015949:1180755:118187211818721182309438Caldicellulosiruptor lactoaceticus 6A chromosome, complete genome3-dehydroquinate dehydratase1e-50197
NC_014721:1777644:177876117787611779198438Caldicellulosiruptor kristjanssonii 177R1B chromosome, complete3-dehydroquinate dehydratase, type ii9e-50195
NC_014720:1161841:118104711810471181484438Caldicellulosiruptor kronotskyensis 2002 chromosome, complete3-dehydroquinate dehydratase, type ii1e-49194
NC_014652:1032711:107351410735141073951438Caldicellulosiruptor hydrothermalis 108 chromosome, complete3-dehydroquinate dehydratase, type ii1e-49194
NC_014392:969498:100871310087131009150438Caldicellulosiruptor obsidiansis OB47 chromosome, complete genome3-dehydroquinate dehydratase, type II4e-49193
NC_014657:1518721:151872115187211519158438Caldicellulosiruptor owensensis OL chromosome, complete genome3-dehydroquinate dehydratase, type ii6e-49192
NC_009437:2367842:236894123689412369378438Caldicellulosiruptor saccharolyticus DSM 8903, complete genome3-dehydroquinate dehydratase, type II7e-47185
NC_003454:677699:683882683882684325444Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete3-dehydroquinate dehydratase5e-45179
NC_009483:2086021:211378021137802114214435Geobacter uraniireducens Rf4 chromosome, complete genome3-dehydroquinate dehydratase5e-40162
NC_015499:1372361:139041613904161390868453Thermodesulfobium narugense DSM 14796 chromosome, complete genome3-dehydroquinate dehydratase6e-40162
NC_014166:716000:737990737990738472483Arcobacter nitrofigilis DSM 7299 chromosome, complete genome3-dehydroquinate dehydratase4e-39159
NC_013204:2955500:297969429796942980122429Eggerthella lenta DSM 2243, complete genome3-dehydroquinate dehydratase, type II2e-36150
NC_015161:792955:807728807728808156429Deinococcus proteolyticus MRP chromosome, complete genome3-dehydroquinate dehydratase3e-36150
NC_015164:2859000:286294128629412863363423Bacteroides salanitronis DSM 18170 chromosome, complete genome3-dehydroquinate dehydratase2e-35147
NC_014761:1405408:142770914277091428140432Oceanithermus profundus DSM 14977 chromosome, complete genome3-dehydroquinate dehydratase2e-35147
NC_012039:185607:204322204322204804483Campylobacter lari RM2100, complete genome3-dehydroquinate dehydratase3e-34143
NC_011753:3088952:310264631026463103143498Vibrio splendidus LGP32 chromosome 1, complete genome3-dehydroquinate dehydratase6e-34142
NC_011312:3060371:307397030739703074419450Aliivibrio salmonicida LFI1238 chromosome chromosome 1, complete3-dehydroquinate dehydratase1e-33141
NC_009615:3993187:399513039951303995546417Parabacteroides distasonis ATCC 8503 chromosome, complete genome3-dehydroquinate dehydratase1e-33141
NC_014532:3479674:349660334966033497037435Halomonas elongata DSM 2581, complete genome3-dehydroquinate dehydratase3e-33140
NC_011979:3341099:334271333427133343147435Geobacter sp. FRC-32, complete genome3-dehydroquinate dehydratase, type II3e-33140
NC_017262:623351:642665642665643105441Zymomonas mobilis subsp. mobilis ATCC 10988 chromosome, complete3-dehydroquinate dehydratase5e-33139
NC_020054:4550000:456258945625894563158570Fibrella aestuarina BUZ 2 drat genome3-dehydroquinate dehydratase, type II2e-32137
NC_019960:1658657:168472316847231685145423Prevotella dentalis DSM 3688 chromosome 1, complete sequence3-dehydroquinate dehydratase, type II1e-32137
NC_007963:317291:333413333413333844432Chromohalobacter salexigens DSM 3043, complete genome3-dehydroquinate dehydratase, type II7e-32135
NC_013939:420500:435753435753436196444Deferribacter desulfuricans SSM1, complete genome3-dehydroquinate dehydratase II9e-32135
NC_008816:369074:381090381090381533444Prochlorococcus marinus str. AS9601, complete genomeDehydroquinase class II1e-31135
NC_009840:396319:407357407357407800444Prochlorococcus marinus str. MIT 9215, complete genomeDehydroquinase class II2e-31134
NC_009445:1453132:147651414765141476999486Bradyrhizobium sp. ORS 278 chromosome, complete genome3-dehydroquinate dehydratase8e-31132
NC_008817:387408:400564400564401004441Prochlorococcus marinus str. MIT 9515, complete genomeDehydroquinase class II1e-30131
NC_016893:135845:149893149893150339447Wigglesworthia glossinidia endosymbiont of Glossina morsitans3-dehydroquinate dehydratase8e-30129
NC_014004:1:180641806418492429Candidatus Sulcia muelleri DMIN chromosome, complete genome3-dehydroquinate dehydratase8e-30129
NC_006677:435652:461603461603462085483Gluconobacter oxydans 621H, complete genome3-dehydroquinate dehydratase6e-30129
NC_009953:2106572:212602521260252126456432Salinispora arenicola CNS-205 chromosome, complete genome3-dehydroquinate dehydratase5e-30129
NC_015563:2702787:271796327179632718400438Delftia sp. Cs1-4 chromosome, complete genome3-dehydroquinate dehydratase1e-29128
NC_017986:5467279:548402554840255484462438Pseudomonas putida ND6 chromosome, complete genome3-dehydroquinate dehydratase1e-29128
NC_007963:2555012:257238925723892572826438Chromohalobacter salexigens DSM 3043, complete genome3-dehydroquinate dehydratase, type II3e-29127
NC_014541:475350:520770520770521222453Ferrimonas balearica DSM 9799 chromosome, complete genome3-dehydroquinate dehydratase4e-29126
NC_007577:353755:365710365710366210501Prochlorococcus marinus str. MIT 9312, complete genome3-dehydroquinate dehydratase, type II7e-29125
NC_015672:1921023:194928719492871949718432Flexistipes sinusarabici DSM 4947 chromosome, complete genome3-dehydroquinate dehydratase9e-29125
NC_013521:1976331:199627519962751996700426Sanguibacter keddieii DSM 10542, complete genome3-dehydroquinate dehydratase5e-28122
NC_005070:1837051:184262318426231843063441Synechococcus sp. WH 8102, complete genome3-dehydroquinate dehydratase6e-28122
NC_013522:1683326:170208117020811702500420Thermanaerovibrio acidaminovorans DSM 6589, complete genome3-dehydroquinate dehydratase, type II2e-27121
NC_020409:437781:462702462702463181480Desulfovibrio piezophilus str. nov C1TLV30 chromosome, complete3-dehydroquinate dehydratase2e-27120
NC_012796:2683711:268753526875352688008474Desulfovibrio magneticus RS-1, complete genome3-dehydroquinate dehydratase2e-27120
NC_005956:152497:162862162862163308447Bartonella henselae str. Houston-1, complete genome3-dehydroquinate dehydratase4e-27120
NC_002935:1315019:135527113552711355711441Corynebacterium diphtheriae NCTC 13129, complete genome3-dehydroquinate dehydratase5e-27119
NC_016782:1316467:132896313289631329403441Corynebacterium diphtheriae 241 chromosome, complete genome3-dehydroquinate dehydratase5e-27119
NC_016783:1313008:135326313532631353703441Corynebacterium diphtheriae INCA 402 chromosome, complete genome3-dehydroquinate dehydratase5e-27119
NC_016785:1297208:131054613105461310986441Corynebacterium diphtheriae CDCE 8392 chromosome, complete genome3-dehydroquinate dehydratase5e-27119
NC_016786:1316436:132893313289331329373441Corynebacterium diphtheriae HC01 chromosome, complete genome3-dehydroquinate dehydratase5e-27119
NC_016787:1276983:131838113183811318821441Corynebacterium diphtheriae HC03 chromosome, complete genome3-dehydroquinate dehydratase5e-27119
NC_016788:1315877:132837413283741328814441Corynebacterium diphtheriae HC04 chromosome, complete genome3-dehydroquinate dehydratase5e-27119
NC_016789:1334514:137477113747711375211441Corynebacterium diphtheriae PW8 chromosome, complete genome3-dehydroquinate dehydratase5e-27119
NC_016790:1259356:129576312957631296203441Corynebacterium diphtheriae VA01 chromosome, complete genome3-dehydroquinate dehydratase5e-27119
NC_016799:1343020:138441513844151384855441Corynebacterium diphtheriae 31A chromosome, complete genome3-dehydroquinate dehydratase5e-27119
NC_016800:1344189:135752713575271357967441Corynebacterium diphtheriae BH8 chromosome, complete genome3-dehydroquinate dehydratase5e-27119
NC_016802:1317365:132986213298621330302441Corynebacterium diphtheriae HC02 chromosome, complete genome3-dehydroquinate dehydratase5e-27119
NC_016803:465453:482586482586483044459Desulfovibrio desulfuricans ND132 chromosome, complete genome3-dehydroquinate dehydratase5e-27119
NC_016801:1361597:137409113740911374531441Corynebacterium diphtheriae C7 (beta) chromosome, complete genome3-dehydroquinate dehydratase9e-27118
NC_016629:3308329:331996333199633320433471Desulfovibrio africanus str. Walvis Bay chromosome, complete3-dehydroquinate dehydratase3e-26117
NC_014150:582093:587705587705588145441Brachyspira murdochii DSM 12563 chromosome, complete genome3-dehydroquinate dehydratase6e-26116
NC_005955:139907:150289150289150735447Bartonella quintana str. Toulouse, complete genome3-dehydroquinate dehydratase1e-25115
NC_013124:1784117:180166118016611802122462Acidimicrobium ferrooxidans DSM 10331, complete genome3-dehydroquinate dehydratase, type II6e-25112
NC_014391:2579919:261162026116202612051432Micromonospora aurantiaca ATCC 27029 chromosome, complete genome3-dehydroquinate dehydratase4e-24110
NC_007712:254000:273291273291273743453Sodalis glossinidius str. 'morsitans', complete genome3-dehydroquinate dehydratase II2e-2097.8
NC_008314:477722:524548524548525009462Ralstonia eutropha H16 chromosome 2, complete sequence3-Dehydroquinate dehydratase2e-1994