Pre_GI: BLASTP Hits

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Query: NC_003366:863437:875075 Clostridium perfringens str. 13, complete genome

Start: 875075, End: 875890, Length: 816

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008261:817295:828901828901829716816Clostridium perfringens ATCC 13124, complete genomeshikimate 5-dehydrogenase2e-143508
NC_008262:784878:814079814079814894816Clostridium perfringens SM101, complete genomeshikimate 5-dehydrogenase1e-141502
NC_015425:2528549:255259725525972553409813Clostridium botulinum BKT015925 chromosome, complete genomeshikimate 5-dehydrogenase3e-69261
NC_008593:2281896:230243323024332303245813Clostridium novyi NT, complete genomeshikimate 5-dehydrogenase7e-66250
NC_014614:2500301:250359825035982504434837Clostridium sticklandii, complete genomeShikimate dehydrogenase1e-56219
NC_003454:677699:683152683152683901750Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeShikimate 5-dehydrogenase3e-42172
NC_009922:42696:466674666747527861Alkaliphilus oremlandii OhILAs, complete genomeshikimate 5-dehydrogenase4e-40165
NC_015387:1091403:111343611134361114248813Marinithermus hydrothermalis DSM 14884 chromosome, complete genomeShikimate dehydrogenase8e-39160
NC_014122:549932:588069588069588902834Methanocaldococcus infernus ME chromosome, complete genomeshikimate 5-dehydrogenase1e-38159
NC_014960:216965:223354223354224232879Anaerolinea thermophila UNI-1, complete genomeshikimate dehydrogenase4e-36151
NC_019977:253895:258493258493259314822Methanomethylovorans hollandica DSM 15978, complete genomeshikimate 5-dehydrogenase2e-35149
NC_014804:341663:351086351086351904819Thermococcus barophilus MP chromosome, complete genomeshikimate 5-dehydrogenase I alpha4e-35148
NC_012108:2542328:254495725449572545772816Desulfobacterium autotrophicum HRM2, complete genomeAroE12e-34146
NC_015474:252390:275352275352276173822Pyrococcus sp. NA2 chromosome, complete genomeshikimate 5-dehydrogenase5e-34144
NC_000868:416958:432656432656433450795Pyrococcus abyssi GE5, complete genomeshikimate 5-dehydrogenase6e-33141
NC_005042:1719055:173579817357981736700903Prochlorococcus marinus subsp. marinus str. CCMP1375, completeShikimate 5-dehydrogenase3e-30132
NC_008044:3024125:302898630289863029816831Silicibacter sp. TM1040, complete genomeshikimate 5-dehydrogenase5e-30131
NC_011979:3712845:373034837303483731220873Geobacter sp. FRC-32, complete genomeshikimate 5-dehydrogenase3e-29129
NC_014355:399938:404381404381405235855Candidatus Nitrospira defluvii, complete genomeshikimate 5-dehydrogenase4e-29128
NC_009952:3596399:363194536319453632781837Dinoroseobacter shibae DFL 12, complete genomeshikimate dehydrogenase5e-29128
NC_012880:1585255:158825915882591589128870Dickeya dadantii Ech703, complete genomeShikimate dehydrogenase substrate binding domain protein3e-28125
NC_015519:1888917:189192318919231892795873Tepidanaerobacter sp. Re1 chromosome, complete genomeShikimate dehydrogenase3e-28125
NC_009785:1414892:141729314172931418150858Streptococcus gordonii str. Challis substr. CH1, complete genomeshikimate 5-dehydrogenase2e-28125
NC_014221:554764:561386561386562216831Truepera radiovictrix DSM 17093 chromosome, complete genomeshikimate 5-dehydrogenase1e-27123
NC_002946:1556000:157380215738021574611810Neisseria gonorrhoeae FA 1090, complete genomeputative shikimate dehydrogenase4e-27122
NC_011035:1564821:158304715830471583886840Neisseria gonorrhoeae NCCP11945 chromosome, complete genomeputative shikimate dehydrogenase4e-27122
NC_017511:1467090:148588314858831486722840Neisseria gonorrhoeae TCDC-NG08107 chromosome, complete genomeputative shikimate dehydrogenase4e-27122
NC_012588:1655615:166559216655921666401810Sulfolobus islandicus M.14.25 chromosome, complete genomeshikimate dehydrogenase substrate binding domain-containing protein3e-27122
NC_012632:1785210:179149017914901792299810Sulfolobus islandicus M.16.27 chromosome, complete genomeshikimate dehydrogenase3e-27122
NC_012726:1685442:169172216917221692531810Sulfolobus islandicus M.16.4 chromosome, complete genomeshikimate dehydrogenase3e-27122
NC_017275:1705827:171580417158041716613810Sulfolobus islandicus HVE10/4 chromosome, complete genomeshikimate dehydrogenase3e-27122
NC_007181:141299:149768149768150559792Sulfolobus acidocaldarius DSM 639, complete genomeshikimate/quinate 5-dehydrogenase2e-27122
NC_004741:1792442:179361417936141794480867Shigella flexneri 2a str. 2457T, complete genomeshikimate 5-dehydrogenase5e-27121
NC_015573:1979202:198059219805921981548957Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomeShikimate dehydrogenase1e-26120
NC_013730:834500:860262860262861005744Spirosoma linguale DSM 74, complete genomeShikimate dehydrogenase substrate binding domain protein1e-26120
NC_007955:2074844:209948120994812100290810Methanococcoides burtonii DSM 6242, complete genomeshikimate 5-dehydrogenase3e-26119
NC_016633:1798758:181916918191691820050882Sphaerochaeta pleomorpha str. Grapes chromosome, complete genomeshikimate 5-dehydrogenase6e-26117
NC_017518:2041282:205627220562722057081810Neisseria meningitidis NZ-05/33 chromosome, complete genomeshikimate 5-dehydrogenase7e-26117
NC_017514:1885154:190204319020431902852810Neisseria meningitidis M01-240149 chromosome, complete genomeshikimate 5-dehydrogenase7e-26117
NC_017513:1845069:186073918607391861548810Neisseria meningitidis G2136 chromosome, complete genomeshikimate 5-dehydrogenase9e-26117
NC_015518:1095879:110422611042261105014789Acidianus hospitalis W1 chromosome, complete genomeShikimate dehydrogenase substrate binding domain-containing protein1e-25117
NC_010120:1814592:183351518335151834324810Neisseria meningitidis 053442, complete genomeshikimate dehydrogenase2e-25116
NC_007802:179780:187014187014187850837Jannaschia sp. CCS1, complete genomeShikimate 5-dehydrogenase2e-25115
NC_003116:2063500:207914620791462079961816Neisseria meningitidis Z2491, complete genomeshikimate dehydrogenase5e-25114
NC_017516:364404:364404364404365213810Neisseria meningitidis H44/76 chromosome, complete genomeshikimate 5-dehydrogenase1e-24113
NC_003112:364869:364869364869365678810Neisseria meningitidis MC58, complete genomeshikimate 5-dehydrogenase1e-24113
NC_008767:1829500:184875318487531849562810Neisseria meningitidis FAM18, complete genomeshikimate dehydrogenase1e-24113
NC_017512:1824966:184383718438371844646810Neisseria meningitidis WUE 2594, complete genomeshikimate dehydrogenase1e-24113
NC_013016:1801000:181996818199681820777810Neisseria meningitidis alpha14 chromosome, complete genomeshikimate 5-dehydrogenase2e-24113
NC_002695:4153394:416503241650324165850819Escherichia coli O157:H7 str. Sakai, complete genomeshikimate 5-dehydrogenase3e-23108
NC_015846:924087:926519926519927265747Capnocytophaga canimorsus Cc5 chromosome, complete genomeshikimate dehydrogenase8e-23107
NC_015151:1403500:140835914083591409162804Vulcanisaeta moutnovskia 768-28 chromosome, complete genomeshikimate dehydrogenase substrate binding domain protein7e-23107
CP002185:3627992:364298936429893643807819Escherichia coli W, complete genomedehydroshikimate reductase, NAD(P)-binding protein1e-22106
NC_015977:2807782:284480328448032845672870Roseburia hominis A2-183 chromosome, complete genomeshikimate 5-dehydrogenase2e-22106
NC_008343:2389710:239037423903742391243870Granulibacter bethesdensis CGDNIH1, complete genomeshikimate 5-dehydrogenase7e-22104
NC_014924:3065430:308387430838743084725852Pseudoxanthomonas suwonensis 11-1 chromosome, complete genomeshikimate 5-dehydrogenase1e-21103
NC_008577:44184:486384863849516879Shewanella sp. ANA-3 chromosome 1, complete sequenceshikimate 5-dehydrogenase2e-21103
NC_010067:4149298:414990241499024150723822Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein4e-2099
NC_008258:1750964:175531417553141756063750Shigella flexneri 5 str. 8401, complete genomeputative oxidoreductase3e-2099
NC_010814:1739706:176001217600121760893882Geobacter lovleyi SZ, complete genomeshikimate 5-dehydrogenase4e-2098.6
NC_009440:1810301:181730518173051818123819Metallosphaera sedula DSM 5348 chromosome, complete genomeshikimate dehydrogenase4e-2098.6
NC_010125:1:145151451515372858Gluconacetobacter diazotrophicus PAl 5, complete genomeputative shikimate dehydrogenase5e-2098.2
NC_015580:1302000:132602613260261326904879Novosphingobium sp. PP1Y, complete genomeshikimate 5-dehydrogenase8e-2097.4
NC_013282:3962188:397488539748853975703819Cronobacter turicensis, complete genomeShikimate dehydrogenase9e-2097.4
NC_008010:105665:115638115638116507870Deinococcus geothermalis DSM 11300 plasmid 1, complete sequenceShikimate dehydrogenase substrate binding-like1e-1996.7
NC_006511:3364448:337965333796533380471819Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCCshikimate 5-dehydrogenase3e-1995.9
NC_009921:8549757:861204286120428612860819Frankia sp. EAN1pec, complete genomeShikimate dehydrogenase substrate binding domain protein4e-1995.1
NC_002947:4293252:429723042972304298069840Pseudomonas putida KT2440, complete genomeshikimate 5-dehydrogenase6e-1994.7
NC_003106:2272313:228195322819532282735783Sulfolobus tokodaii str. 7, complete genomehypothetical shikimate 5-dehydrogenase8e-1994.4
NC_009512:2238437:225730122573012258122822Pseudomonas putida F1, complete genomeShikimate dehydrogenase substrate binding, N-terminal domain protein1e-1893.6
NC_009921:8549757:855440285544028555274873Frankia sp. EAN1pec, complete genomeShikimate dehydrogenase substrate binding domain protein4e-1892
NC_007614:620500:620577620577621410834Nitrosospira multiformis ATCC 25196 chromosome 1, completeshikimate 5-dehydrogenase4e-1892
NC_015563:2702787:270994927099492710788840Delftia sp. Cs1-4 chromosome, complete genomeShikimate dehydrogenase4e-1891.7
NC_006155:2893802:289966628996662900484819Yersinia pseudotuberculosis IP 32953, complete genomeshikimate 5-dehydrogenase6e-1891.3
NC_010634:2810815:281667928166792817497819Yersinia pseudotuberculosis PB1/+, complete genomeshikimate dehydrogenase substrate binding subunit6e-1891.3
NC_001263:72681:783807838079201822Deinococcus radiodurans R1 chromosome 1, complete sequenceshikimate 5-dehydrogenase2e-1686.3
NC_019791:99793:104742104742105488747Caldisphaera lagunensis DSM 15908 chromosome, complete genomeshikimate 5-dehydrogenase6e-1684.7
NC_016932:832748:837471837471838286816Corynebacterium pseudotuberculosis 316 chromosome, complete genomeshikimate 5-dehydrogenase9e-1684.3
NC_014329:844622:849345849345850160816Corynebacterium pseudotuberculosis FRC41 chromosome, completeshikimate 5-dehydrogenase9e-1684.3
NC_012779:3176820:323099232309923231780789Edwardsiella ictaluri 93-146, complete genomehypothetical protein1e-1584
NC_015470:831863:8318638318638332961434Chlamydophila psittaci 6BC chromosome, complete genomebifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein1e-1584
NC_017291:829577:8295778295778310101434Chlamydophila psittaci C19/98 chromosome, complete genomebifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein1e-1584
NC_016781:844613:849336849336850037702Corynebacterium pseudotuberculosis 3/99-5 chromosome, completeshikimate 5-dehydrogenase2e-1583.2
NC_007963:317291:332550332550333416867Chromohalobacter salexigens DSM 3043, complete genomeShikimate 5-dehydrogenase2e-1479.7
NC_006087:28490:300263002630745720Leifsonia xyli subsp. xyli str. CTCB07, complete genomeshikimate 5-dehydrogenase3e-1479.3
NC_009512:3068495:306768030676803068498819Pseudomonas putida F1, complete genomeshikimate 5-dehydrogenase3e-1479.3
NC_005061:214168:237684237684238568885Candidatus Blochmannia floridanus, complete genomeshikimate 5-dehydrogenase3e-1479
NC_015424:4251369:427545242754524276273822Aeromonas veronii B565 chromosome, complete genomeShikimate dehydrogenase8e-1477.8
NC_017986:5467279:548320254832025484020819Pseudomonas putida ND6 chromosome, complete genomeshikimate 5-dehydrogenase1e-1377
NC_008513:343540:353033353033353875843Buchnera aphidicola str. Cc (Cinara cedri), complete genomeAroE2e-1376.3
NC_013522:1683326:170519917051991706059861Thermanaerovibrio acidaminovorans DSM 6589, complete genomeShikimate dehydrogenase substrate binding domain protein3e-1375.9
NC_009664:3969609:397398339739833974843861Kineococcus radiotolerans SRS30216, complete genomeShikimate dehydrogenase substrate binding domain protein5e-1375.1
NC_016782:1316467:133288813328881333730843Corynebacterium diphtheriae 241 chromosome, complete genomeshikimate 5-dehydrogenase8e-1374.3
NC_016786:1316436:133285813328581333700843Corynebacterium diphtheriae HC01 chromosome, complete genomeshikimate 5-dehydrogenase8e-1374.3
NC_016783:1313008:135718813571881358030843Corynebacterium diphtheriae INCA 402 chromosome, complete genomeshikimate 5-dehydrogenase8e-1374.3
NC_016788:1315877:133229913322991333141843Corynebacterium diphtheriae HC04 chromosome, complete genomeshikimate 5-dehydrogenase8e-1374.3
NC_002935:1315019:135919613591961360065870Corynebacterium diphtheriae NCTC 13129, complete genomeshikimate 5-dehydrogenase8e-1374.3
NC_016790:1259356:129968812996881300530843Corynebacterium diphtheriae VA01 chromosome, complete genomeshikimate 5-dehydrogenase1e-1273.9
NC_016787:1276983:132230613223061323148843Corynebacterium diphtheriae HC03 chromosome, complete genomeshikimate 5-dehydrogenase1e-1273.9
NC_016785:1297208:131447113144711315313843Corynebacterium diphtheriae CDCE 8392 chromosome, complete genomeshikimate 5-dehydrogenase2e-1272.8
NC_014727:95875:953469534695906561Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,shikimate 5-dehydrogenase and fad-dependent oxidase domain3e-1272.8
NC_016802:1317365:133378713337871334629843Corynebacterium diphtheriae HC02 chromosome, complete genomeshikimate 5-dehydrogenase4e-1272
NC_016789:1334514:137869613786961379538843Corynebacterium diphtheriae PW8 chromosome, complete genomeshikimate 5-dehydrogenase4e-1272
NC_016799:1343020:138834013883401389182843Corynebacterium diphtheriae 31A chromosome, complete genomeshikimate 5-dehydrogenase4e-1272
NC_016800:1344189:136145213614521362294843Corynebacterium diphtheriae BH8 chromosome, complete genomeshikimate 5-dehydrogenase4e-1272
NC_016801:1361597:137801613780161378858843Corynebacterium diphtheriae C7 (beta) chromosome, complete genomeshikimate 5-dehydrogenase4e-1272
NC_004545:499709:511465511465512313849Buchnera aphidicola str. Bp (Baizongia pistaciae), complete genomeshikimate 5-dehydrogenase7e-1271.2
NC_008786:2489104:249396824939682494834867Verminephrobacter eiseniae EF01-2, complete genomeshikimate 5-dehydrogenase9e-1270.9
NC_014109:393500:414783414783415619837Candidatus Riesia pediculicola USDA chromosome, complete genomeshikimate 5-dehydrogenase1e-1170.5
NC_010557:316000:330534330534331370837Burkholderia ambifaria MC40-6 chromosome 3, complete sequenceShikimate dehydrogenase substrate binding domain protein3e-1169.3
NC_004061:540354:543669543669544490822Buchnera aphidicola str. Sg (Schizaphis graminum), complete genomeshikimate 5-dehydrogenase8e-1064.3
NC_015435:354837:367346367346367900555Metallosphaera cuprina Ar-4 chromosome, complete genomeshikimate dehydrogenase1e-0963.9
NC_013521:1976331:197885019788501979704855Sanguibacter keddieii DSM 10542, complete genomeshikimate 5-dehydrogenase1e-0860.5
NC_013446:2164974:218289021828902183702813Comamonas testosteroni CNB-2, complete genomeshikimate 5-dehydrogenase5e-0858.5
NC_016002:2652500:267029226702922671170879Pseudogulbenkiania sp. NH8B, complete genomeshikimate dehydrogenase substrate binding domain containing protein8e-0857.8
NC_015563:2702787:271476127147612715594834Delftia sp. Cs1-4 chromosome, complete genomeShikimate dehydrogenase3e-0652.4