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Query: NC_003366:863437:873958 Clostridium perfringens str. 13, complete genome

Start: 873958, End: 874251, Length: 294

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008261:817295:827786827786828079294Clostridium perfringens ATCC 13124, complete genomechorismate mutase1e-48191
NC_008262:784878:812966812966813259294Clostridium perfringens SM101, complete genomechorismate mutase8e-47185
NC_015425:2528549:255342225534222553712291Clostridium botulinum BKT015925 chromosome, complete genomechorismate mutase4e-1476.6
NC_008593:2281896:230325723032572303529273Clostridium novyi NT, complete genomechorismate mutase3e-1270.5
NC_009253:829913:8379458379458390871143Desulfotomaculum reducens MI-1 chromosome, complete genomeprephenate dehydratase3e-1063.5
NC_014614:757381:7732637732637743721110Clostridium sticklandii, complete genomePheA4e-0960.1
NC_003454:677699:682841682841683101261Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeShikimate 5-dehydrogenase1e-0755.5