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Query: NC_003366:863437:863437 Clostridium perfringens str. 13, complete genome

Start: 863437, End: 868497, Length: 5061

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008261:817295:8172958172958223555061Clostridium perfringens ATCC 13124, complete genomeFibronectin type III domain protein03325
NC_012466:318675:3351993351993405025304Streptococcus pneumoniae JJA, complete genomeendo-alpha-N-acetylgalactosaminidase1e-99365
NC_014638:321382:3213823213823271775796Bifidobacterium bifidum PRL2010 chromosome, complete genomeendo-alpha-N-acetylgalactosaminidase, cellwall anchor protein family1e-97359
NC_016938:193000:2166952166952206783984Melissococcus plutonius DAT561 chromosome 1, complete genomebacterial Ig-like domain protein1e-94348
NC_013171:1808000:1816919181691918228315913Anaerococcus prevotii DSM 20548, complete genomecoagulation factor 5/8 type domain protein1e-88329
NC_008262:784878:807225807225807704480Clostridium perfringens SM101, complete genomeFibronectin type III domain protein3e-62241
NC_003366:1427785:1439365143936514423703006Clostridium perfringens str. 13, complete genomehyaluronidase2e-25119
NC_003366:1427785:144259814425981443551954Clostridium perfringens str. 13, complete genomehypothetical protein2e-1793.2
NC_015519:801929:8143308143308198075478Tepidanaerobacter sp. Re1 chromosome, complete genomebeta-galactosidase1e-0760.8
NC_009785:1534454:1535957153595715430097053Streptococcus gordonii str. Challis substr. CH1, complete genomebeta-galactosidase1e-0657.4
NC_015291:665714:6657146657146726916978Streptococcus oralis Uo5, complete genomebeta-galactosidase1e-0657
NC_015690:1772015:1772015177201517760674053Paenibacillus mucilaginosus KNP414 chromosome, complete genomeXynA4e-0655.1
NC_016935:2302055:2302055230205523061074053Paenibacillus mucilaginosus 3016 chromosome, complete genomeprotein XynA5e-0655.1
NC_021175:1635796:1642681164268116494696789Streptococcus oligofermentans AS 1.3089, complete genomebeta-galactosidase7e-0654.7