Pre_GI: BLASTP Hits

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Query: NC_003366:461602:482148 Clostridium perfringens str. 13, complete genome

Start: 482148, End: 484355, Length: 2208

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012926:140000:1574411574411596422202Streptococcus suis BM407 chromosome, complete genomealpha-galactosidase0844
NC_012924:142500:1574621574621596632202Streptococcus suis SC84, complete genomealpha-galactosidase0844
NC_009443:142500:1573691573691595702202Streptococcus suis 98HAH33, complete genomeAlpha-galactosidase0844
NC_009442:142500:1574671574671596682202Streptococcus suis 05ZYH33 chromosome, complete genomealpha-galactosidase0844
NC_012925:140000:1576571576571598582202Streptococcus suis P1/7, complete genomealpha-galactosidase0844
NC_013171:75110:9061990619928382220Anaerococcus prevotii DSM 20548, complete genomeglycoside hydrolase clan GH-D0818
NC_019896:1989997:1994831199483119970712241Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completeAlpha-galactosidase GalA0801
NC_020291:5808856:5839386583938658416142229Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomealpha-galactosidase 10784
NC_010610:2013659:2022493202249320247152223Lactobacillus fermentum IFO 3956, complete genomealpha-galactosidase0776
NC_019978:2506472:2523974252397425261632190Halobacteroides halobius DSM 5150, complete genomealpha-galactosidase0722
NC_008261:576923:5858665858665880702205Clostridium perfringens ATCC 13124, complete genomealpha-galactosidase0676
NC_016023:579000:5998295998296020212193Bacillus coagulans 36D1 chromosome, complete genomeglycoside hydrolase clan GH-D0655
NC_015634:652000:6528886528886550802193Bacillus coagulans 2-6 chromosome, complete genomeglycoside hydrolase clan GH-D0651
NC_015949:1301004:1301004130100413031932190Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomeglycoside hydrolase clan GH-D0650
NC_014828:1905479:1917267191726719194532187Ethanoligenens harbinense YUAN-3 chromosome, complete genomeAlpha-galactosidase0644
NC_016935:4813916:4825202482520248273672166Paenibacillus mucilaginosus 3016 chromosome, complete genomeglycoside hydrolase0636
NC_008525:561000:5640975640975662982202Pediococcus pentosaceus ATCC 25745, complete genomeAlpha-galactosidase1e-178627
NC_013656:2317224:2327238232723823294542217Lactococcus lactis subsp. lactis KF147, complete genomealpha-galactosidase9e-177620
NC_015275:3594890:3602588360258836049302343Clostridium lentocellum DSM 5427 chromosome, complete genomeAlpha-galactosidase2e-147523
NC_008525:561000:5697965697965719552160Pediococcus pentosaceus ATCC 25745, complete genomeAlpha-galactosidase5e-130465
NC_006347:625328:6272746272746294422169Bacteroides fragilis YCH46, complete genomealpha-galactosidase6e-96352
NC_009615:487173:5132425132425154492208Parabacteroides distasonis ATCC 8503 chromosome, complete genomealpha-glycosidase3e-95350
NC_016776:625628:6307376307376329052169Bacteroides fragilis 638R, complete genomeputative melibiase5e-94345
NC_015164:1952500:1967188196718819694012214Bacteroides salanitronis DSM 18170 chromosome, complete genomeAlpha-galactosidase8e-91335
NC_012912:2998511:3014857301485730169862130Dickeya zeae Ech1591, complete genomeglycoside hydrolase clan GH-D2e-85317
NC_010159:1710268:1733307173330717354332127Yersinia pestis Angola, complete genomealpha-galactosidase AgaN2e-84313
NC_010634:1916000:1955777195577719579032127Yersinia pseudotuberculosis PB1/+, complete genomeglycoside hydrolase clan GH-D3e-84313
NC_006155:1916426:1955793195579319579192127Yersinia pseudotuberculosis IP 32953, complete genomealpha-galactosidase3e-84313
NC_009078:2718741:2753383275338327555932211Burkholderia pseudomallei 1106a chromosome II, complete sequencealpha-galactosidase2e-82307
NC_016613:2103792:2123401212340121255032103Vibrio sp. EJY3 chromosome 1, complete sequencealpha-galactosidase2e-82307
NC_007435:1446916:1481558148155814837292172Burkholderia pseudomallei 1710b chromosome II, complete sequencealpha-galactosidase4e-82306
NC_013235:1938889:1940433194043319426762244Nakamurella multipartita DSM 44233, complete genomeglycoside hydrolase clan GH-D1e-80301
NC_013235:1938889:1947622194762219497782157Nakamurella multipartita DSM 44233, complete genomeglycoside hydrolase clan GH-D1e-75284
NC_014246:288847:2999342999343019251992Mobiluncus curtisii ATCC 43063 chromosome, complete genomeputative alpha-galactosidase6e-71269
NC_008043:499399:5175805175805196462067Silicibacter sp. TM1040 mega plasmid, complete sequenceglycoside hydrolase, clan GH-D8e-69262
NC_014656:1704101:1706868170686817091742307Bifidobacterium longum subsp. longum BBMN68 chromosome, completegala11e-68261
NC_014169:2407266:2422093242209324243992307Bifidobacterium longum subsp. longum JDM301 chromosome, completeglycoside hydrolase2e-68260
NC_015520:2821406:2834385283438528364602076Mahella australiensis 50-1 BON chromosome, complete genomealpha-galactosidase7e-38159
NC_013526:439813:4769504769504789231974Thermobaculum terrenum ATCC BAA-798 chromosome 2, complete genomeglycoside hydrolase clan GH-D2e-30134
NC_013714:570329:5769235769235790612139Bifidobacterium dentium Bd1, complete genomeputative glycosidase4e-22107
NC_016628:935420:9563259563259579861662Vibrio furnissii NCTC 11218 chromosome 2, complete sequenceglycoside hydrolase, clan GH-D1e-21105
NC_013037:6209424:6247949624794962500512103Dyadobacter fermentans DSM 18053, complete genomeglycoside hydrolase clan GH-D6e-2099.8
NC_013530:3204825:3237735323773532398552121Xylanimonas cellulosilytica DSM 15894, complete genomeglycoside hydrolase clan GH-D4e-1894
NC_015577:3621777:3629551362955136315602010Treponema azotonutricium ZAS-9 chromosome, complete genomehypothetical protein1e-1068.9
NC_015424:2316228:2346023234602323477321710Aeromonas veronii B565 chromosome, complete genomealpha-galactosidase4e-0860.5
NC_015389:1610756:1610756161075616124951740Coriobacterium glomerans PW2 chromosome, complete genomehypothetical protein6e-0860.1
NC_015957:7533000:7543594754359475456692076Streptomyces violaceusniger Tu 4113 chromosome, complete genomeglycoside hydrolase clan GH-D5e-0757
NC_016631:1117241:1138875113887511413672493Granulicella mallensis MP5ACTX8 chromosome, complete genomeglycoside hydrolase clan GH-D5e-0757
NC_012483:971592:9854359854359878552421Acidobacterium capsulatum ATCC 51196, complete genomemelibiase family/PKD domain protein2e-0654.7