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Query: NC_003366:461602:473520 Clostridium perfringens str. 13, complete genome

Start: 473520, End: 477425, Length: 3906

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000964:2049899:2064635206463520682403606Bacillus subtilis subsp. subtilis str. 168, complete genomehypothetical protein8e-102372
NC_015873:924392:9529519529519566613711Megasphaera elsdenii DSM 20460, complete genomehypothetical protein9e-61236
NC_017191:2174741:2192256219225621935301275Bacillus amyloliquefaciens XH7 chromosome, complete genomehypothetical protein2e-53211
NC_017190:1196356:1207991120799112092651275Bacillus amyloliquefaciens LL3 chromosome, complete genomeNTPase with transmembrane helices2e-53211
NC_017188:2172706:2190221219022121914951275Bacillus amyloliquefaciens TA208 chromosome, complete genomeNTPase with transmembrane helices2e-53211
NC_014551:1279229:1290863129086312921371275Bacillus amyloliquefaciens DSM 7, complete genomeNTPase with transmembrane helices2e-53211
NC_008054:1649160:1657684165768416613313648Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, completehypothetical protein4e-48194
NC_004663:6223442:6225109622510962287773669Bacteroides thetaiotaomicron VPI-5482, complete genomehypothetical protein2e-47192
NC_015737:1976000:1985758198575819894413684Clostridium sp. SY8519, complete genomehypothetical protein4e-47191
NC_015633:338000:3416733416733452783606Vibrio anguillarum 775 chromosome chromosome I, complete sequenceDNA-binding protein3e-44181
NC_017188:2172706:2187882218788221900862205Bacillus amyloliquefaciens TA208 chromosome, complete genomeNTPase with transmembrane helices5e-37157
NC_017190:1196356:1209313120931312116042292Bacillus amyloliquefaciens LL3 chromosome, complete genomemembrane protein yobI8e-37156
NC_017191:2174741:2189917218991721922082292Bacillus amyloliquefaciens XH7 chromosome, complete genomeNTPase with transmembrane helices8e-37156
NC_019968:1304450:1318172131817213217923621Prevotella dentalis DSM 3688 chromosome 2, complete sequencehypothetical protein5e-32140
NC_017068:1143515:1190078119007811937313654Selenomonas ruminantium subsp. lactilytica TAM6421, completehypothetical protein1e-31139
NC_008027:2909000:2914603291460329185503948Pseudomonas entomophila L48, complete genomehypothetical protein1e-29132
NC_014842:19411:3600036000398273828Pantoea sp. At-9b plasmid pPAT9B05, complete sequencehypothetical protein1e-26123
NC_015942:763500:7668197668197705083690Acidithiobacillus ferrivorans SS3 chromosome, complete genomehypothetical protein2e-24115
NC_015635:4864349:4872764487276448764443681Microlunatus phosphovorus NM-1, complete genomehypothetical protein6e-24114
NC_009480:1261961:1270661127066112742783618Clavibacter michiganensis subsp. michiganensis NCPPB 382, completehypothetical protein7e-22107
NC_018691:1293449:1299528129952813032533726Alcanivorax dieselolei B5 chromosome, complete genomehypothetical protein1e-20103
NC_014551:1279229:1293016129301612944701455Bacillus amyloliquefaciens DSM 7, complete genomehypothetical protein2e-20102
NC_014551:1279229:129227112922711293068798Bacillus amyloliquefaciens DSM 7, complete genomehypothetical protein3e-1378.6
NC_016860:3995445:400859540085954009548954Salmonella enterica subsp. enterica serovar Typhimurium strhypothetical protein1e-1173.6