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Query: NC_003366:2356148:2375540 Clostridium perfringens str. 13, complete genome

Start: 2375540, End: 2376148, Length: 609

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:2242432:226189922618992262507609Clostridium perfringens SM101, complete genomeputative sporulation protein YtaF5e-63240
NC_018664:2279687:227968722796872280298612Clostridium acidurici 9a chromosome, complete genomeputative sporulation protein2e-21102
NC_014393:3425694:344131034413103441930621Clostridium cellulovorans 743B chromosome, complete genomesporulation protein YtaF7e-21100
NC_015589:2941953:295053929505392951198660Desulfotomaculum ruminis DSM 2154 chromosome, complete genomesporulation protein YtaF4e-0754.7
NC_010320:1949852:196503219650321965655624Thermoanaerobacter sp. X514 chromosome, complete genomehypothetical protein6e-0754.3
NC_014538:985339:988689988689989312624Thermoanaerobacter sp. X513 chromosome, complete genomesporulation protein YtaF6e-0754.3
NC_011772:4487378:451538045153804516012633Bacillus cereus G9842, complete genomehypothetical protein9e-0753.5
NC_010718:1959517:198139719813971982020624Natranaerobius thermophilus JW/NM-WN-LF, complete genomesporulation protein YtaF5e-0651.2