Pre_GI: BLASTP Hits

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Query: NC_003366:2356148:2365174 Clostridium perfringens str. 13, complete genome

Start: 2365174, End: 2365755, Length: 582

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:2242432:225167022516702252245576Clostridium perfringens SM101, complete genomeDJ-1 family protein7e-94342
NC_021182:2965395:297002429700242970590567Clostridium pasteurianum BC1, complete genomeDJ-1 family protein1e-39162
NC_008609:2254392:2278418227841822795841167Pelobacter propionicus DSM 2379, complete genomemetal dependent phosphohydrolase5e-29127
NC_020134:845164:851079851079851621543Clostridium stercorarium subsp. stercorarium DSM 8532, completeDJ-1 family protein3e-28124
NC_013192:815854:819631819631820194564Leptotrichia buccalis DSM 1135, complete genomeDJ-1 family protein2e-27121
NC_009442:1446508:145045514504551451003549Streptococcus suis 05ZYH33 chromosome, complete genomeintracellular protease/amidase2e-25115
NC_009443:1445936:144988114498811450429549Streptococcus suis 98HAH33, complete genomeintracellular protease/amidase2e-25115
NC_012925:1357783:136173013617301362269540Streptococcus suis P1/7, complete genomeDJ-1/PfpI family protein2e-25115
NC_012924:1446190:145013714501371450676540Streptococcus suis SC84, complete genomeDJ-1/PfpI family protein2e-25115
NC_012926:1496510:150045715004571500996540Streptococcus suis BM407 chromosome, complete genomeDJ-1/PfpI family protein2e-25115
NC_007520:1940120:194539319453931945950558Thiomicrospira crunogena XCL-2, complete genomeDJ-18e-25113
NC_012225:2523262:254132125413212541875555Brachyspira hyodysenteriae WA1, complete genomeThiJ/PfpI domain-containing protein1e-24112
NC_014935:342491:344988344988345548561Nitratifractor saLSUginis DSM 16511 chromosome, complete genomedj-1 family protein2e-24112
NC_008710:621822:652860652860653405546Borrelia turicatae 91E135, complete genome4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme2e-24111
NC_013851:3392644:341080334108033411354552Allochromatium vinosum DSM 180 chromosome, complete genomeDJ-1 family protein9e-23106
NC_013517:4117666:411936641193664119917552Sebaldella termitidis ATCC 33386, complete genomeDJ-1 family protein6e-21100
NC_015501:556994:576024576024576572549Porphyromonas asaccharolytica DSM 20707 chromosome, completeDJ-1 family protein7e-2097.1
NC_013171:312500:325596325596326180585Anaerococcus prevotii DSM 20548, complete genomeDJ-1 family protein8e-2096.7
NC_004663:2935060:295665329566532957231579Bacteroides thetaiotaomicron VPI-5482, complete genomeputative protease/amidase6e-1580.5
NC_004459:1794540:180655918065591807158600Vibrio vulnificus CMCP6 chromosome I, complete sequence4-methyl-5(B-hydroxyethyl)-thiazol monophosphate biosynthesis enzyme1e-1479.7
NC_000961:1481685:149749014974901497990501Pyrococcus horikoshii OT3, complete genomeintracellular proteinase2e-1375.5
NC_002967:2507993:252404225240422524596555Treponema denticola ATCC 35405, complete genomeDJ-1 family protein6e-1373.9
NC_009089:3889811:392039139203913920975585Clostridium difficile 630, complete genomeputative protease2e-1272
NC_013791:1507943:152278015227801523301522Bacillus pseudofirmus OF4 chromosome, complete genomePfpI family intracellular peptidase6e-1270.5
NC_012491:6143928:616239761623976162987591Brevibacillus brevis NBRC 100599, complete genomehypothetical protein6e-1270.5
NC_015474:252390:255828255828256328501Pyrococcus sp. NA2 chromosome, complete genomeintracellular protease2e-1168.9
NC_009725:2784334:279860427986042799113510Bacillus amyloliquefaciens FZB42, complete genomeYraA3e-1168.2
NC_014931:6203872:622084262208426221414573Variovorax paradoxus EPS chromosome, complete genomeintracellular protease, PfpI family6e-1167.4
NC_010163:1193237:119704311970431197588546Acholeplasma laidlawii PG-8A chromosome, complete genomeglutamine amidotransferase superfamily, DJ-1/PfpI family protein6e-1167.4
NC_010322:3315024:333814333381433338685543Pseudomonas putida GB-1 chromosome, complete genomePfpI family intracellular peptidase9e-1166.6
NC_008258:401786:406522406522407112591Shigella flexneri 5 str. 8401, complete genome4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis2e-1065.9
NC_015663:2694373:269966026996602700253594Enterobacter aerogenes KCTC 2190 chromosome, complete genomeoxidative-stress-resistance chaperone4e-1064.7
NC_020181:2714559:274553927455392746132594Enterobacter aerogenes EA1509E, complete genomeDJ-1/YajL/PfpI superfamily, includes chaperone protein YajL (former ThiJ), parkinsonism-associated protein DJ-1, peptidases PfpI, Hsp314e-1064.7
NC_011832:2668337:268854626885462689064519Candidatus Methanosphaerula palustris E1-9c, complete genomeintracellular protease, PfpI family4e-1064.3
NC_017328:385552:390288390288390884597Shigella flexneri 2002017 chromosome, complete genome4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis (ThiJ) protein6e-1063.9
NC_004337:367687:372424372424373020597Shigella flexneri 2a str. 301, complete genome4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis (ThiJ) protein6e-1063.9
NC_004741:366822:371558371558372154597Shigella flexneri 2a str. 2457T, complete genome4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis (ThiJ) protein6e-1063.9
NC_007795:1922000:192232219223221922837516Staphylococcus aureus subsp. aureus NCTC 8325, complete genomehypothetical protein2e-0962.4
NC_009641:1979053:197905319790531979568516Staphylococcus aureus subsp. aureus str. Newman chromosome,ThiJ/PfpI family protein2e-0962.4
NC_017341:1976000:197731519773151977830516Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,intracellular protease2e-0962.4
NC_007955:1:191411914119665525Methanococcoides burtonii DSM 6242, complete genomeThiJ/PfpI8e-0960.1
NC_010617:55493:651266512665716591Kocuria rhizophila DC2201, complete genomePfpI family peptidase1e-0859.3
NC_010510:339879:353090353090353659570Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, completeintracellular protease, PfpI family2e-0858.5
NC_015277:380624:394511394511395071561Sphingobacterium sp. 21 chromosome, complete genomeintracellular protease, PfpI family3e-0858.2
NC_004193:375416:542282542282542806525Oceanobacillus iheyensis HTE831, complete genomeintracellular proteinase1e-0756.2
NC_014222:799229:808760808760809278519Methanococcus voltae A3 chromosome, complete genomeintracellular protease, PfpI family1e-0755.8
NC_014761:516981:529346529346529855510Oceanithermus profundus DSM 14977 chromosome, complete genomeintracellular protease, pfpi family2e-0755.8
NC_017243:2190000:219987921998792200403525Brachyspira intermedia PWS/A chromosome, complete genomeintracellular protease2e-0755.8
NC_017047:2079368:209201820920182092593576Rahnella aquatilis HX2 chromosome, complete genomepeptidase C56, PfpI2e-0755.8
NC_009654:3316458:332973333297333330302570Marinomonas sp. MWYL1, complete genomePfpI family intracellular peptidase2e-0755.5
NC_015161:2060369:207734620773462077915570Deinococcus proteolyticus MRP chromosome, complete genomeintracellular protease, PfpI family2e-0755.5
NC_009051:2097271:212186621218662122420555Methanoculleus marisnigri JR1, complete genomeintracellular protease, PfpI family3e-0755.1
NC_016612:5231065:527763852776385278213576Klebsiella oxytoca KCTC 1686 chromosome, complete genomepeptidase C56, PfpI3e-0755.1
NC_014299:82584:134085134085134639555Halalkalicoccus jeotgali B3 plasmid 2, complete sequenceintracellular protease, PfpI family protein3e-0755.1
NC_016114:648422:650946650946651512567Streptomyces flavogriseus ATCC 33331 chromosome, complete genomePfpi family intracellular protease3e-0754.7
NC_018524:4988810:499194249919424992484543Nocardiopsis alba ATCC BAA-2165 chromosome, complete genomeprotease I3e-0754.7
NC_019964:1873167:188107518810751881629555Halovivax ruber XH-70, complete genomeintracellular protease, PfpI family4e-0754.3
NC_017955:3731480:377152737715273772102576Modestobacter marinus, complete genomeintracellular protease, PfpI family8e-0753.5
NC_014760:101469:117040117040117585546Mycoplasma bovis PG45 chromosome, complete genomeDJ-1/PfpI family protein5e-0651.2