Pre_GI: BLASTP Hits

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Query: NC_003366:2106937:2122664 Clostridium perfringens str. 13, complete genome

Start: 2122664, End: 2123425, Length: 762

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012658:1581486:160164016016401602410771Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein3e-40165
NC_015958:1516944:153706115370611537807747Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeRNA-binding S4 domain-containing protein3e-24112
NC_013515:1391143:139481613948161395553738Streptobacillus moniliformis DSM 12112, complete genomeRNA-binding S4 domain protein1e-23110
NC_013520:1638000:164758116475811648366786Veillonella parvula DSM 2008, complete genomeRNA-binding S4 domain protein2e-23108
NC_014152:2181360:219596121959612196743783Thermincola sp. JR, complete genomeRNA-binding S4 domain protein6e-1994.7
NC_010296:2200054:220214622021462202925780Microcystis aeruginosa NIES-843, complete genomeRNA-binding S45e-1788.2
NC_014248:5196353:520834252083425209121780Nostoc azollae 0708 chromosome, complete genomephotosystem II S4 domain-containing protein5e-1788.2
NC_000911:1718820:173733817373381738117780Synechocystis sp. PCC 6803, complete genomehypothetical protein7e-1684.3
NC_017039:1717848:173636617363661737145780Synechocystis sp. PCC 6803 substr. PCC-P, complete genomehypothetical protein7e-1684.3
NC_017052:1717836:173635417363541737133780Synechocystis sp. PCC 6803 substr. PCC-N, complete genomehypothetical protein7e-1684.3
NC_017277:1717637:173615517361551736934780Synechocystis sp. PCC 6803, complete genomehypothetical protein7e-1684.3
NC_014171:3779956:380202738020273802794768Bacillus thuringiensis BMB171 chromosome, complete genomeRNA binding protein2e-1582.8
NC_004722:3855326:387915638791563879923768Bacillus cereus ATCC 14579, complete genomeRNA binding protein2e-1582.8
NC_011725:3897450:392120839212083921933726Bacillus cereus B4264 chromosome, complete genomeS4 domain-containing protein3e-1582.4
NC_010475:2896000:291754029175402918301762Synechococcus sp. PCC 7002, complete genomeS4 domain protein5e-1581.6
NC_011772:3863166:388728238872823888049768Bacillus cereus G9842, complete genomeS4 domain protein6e-1581.3
NC_011969:3627980:364952836495283650295768Bacillus cereus Q1 chromosome, complete genomes4 domain protein1e-1480.1
NC_011773:3729500:375178037517803752547768Bacillus cereus AH820 chromosome, complete genomeS4 domain-containing protein2e-1479.3
NC_003909:3671468:369498036949803695747768Bacillus cereus ATCC 10987, complete genomeS4 domain protein2e-1479.3
NC_005957:3716487:373918837391883739955768Bacillus thuringiensis serovar konkukian str. 97-27, completeS4 domain protein3e-1479
NC_014335:3645500:366774736677473668514768Bacillus cereus biovar anthracis str. CI chromosome, completeRNA-binding S4 domain-containing protein3e-1479
NC_006274:3773335:379742937974293798196768Bacillus cereus E33L, complete genomeS4 domain protein4e-1478.6
NC_017208:3897253:391880939188093919576768Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeRNA binding protein7e-1477.8
NC_012581:519969:520725520725521492768Bacillus anthracis str. CDC 684 chromosome, complete genomeS4 domain-containing protein1e-1377
NC_007530:3694940:371712137171213717888768Bacillus anthracis str. 'Ames Ancestor', complete genomes4 domain protein1e-1377
NC_011999:813978:821285821285822058774Macrococcus caseolyticus JCSC5402, complete genomehypothetical protein8e-1374.3
NC_014019:4094750:411400141140014114774774Bacillus megaterium QM B1551 chromosome, complete genomeRNA binding protein8e-1270.9
NC_007350:1629694:165121116512111651849639Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305,hypothetical protein2e-0962.8