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Query: NC_003366:2106937:2122025 Clostridium perfringens str. 13, complete genome

Start: 2122025, End: 2122651, Length: 627

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012658:1581486:160242616024261603085660Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative septum site-determining protein divIVA9e-40163
NC_015958:1516944:153654815365481537033486Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeDivIVA domain-containing protein7e-28123
NC_010184:3757000:377648037764803776986507Bacillus weihenstephanensis KBAB4, complete genomeDivIVA family protein3e-1891.7
NC_006274:3773335:379683337968333797339507Bacillus cereus E33L, complete genomecell-division initiation protein (divIVA)4e-1891.3
NC_007530:3694940:371652537165253717031507Bacillus anthracis str. 'Ames Ancestor', complete genomecell-division initiation protein diviva4e-1891.3
NC_005957:3716487:373859237385923739098507Bacillus thuringiensis serovar konkukian str. 97-27, completecell-division initiation protein (divIVA)4e-1891.3
NC_014335:3645500:366715136671513667657507Bacillus cereus biovar anthracis str. CI chromosome, completeDivIVA family protein4e-1891.3
NC_011772:3863166:388668638866863887192507Bacillus cereus G9842, complete genomecell-division initiation protein DivIVA4e-1891.3
NC_004722:3855326:387856038785603879066507Bacillus cereus ATCC 14579, complete genomeCell division protein DIVIVA4e-1891.3
NC_011725:3897450:392061239206123921118507Bacillus cereus B4264 chromosome, complete genomecell-division initiation protein DivIVA4e-1891.3
NC_011773:3729500:375118437511843751690507Bacillus cereus AH820 chromosome, complete genomecell-division initiation protein DivIVA4e-1891.3
NC_012581:519969:521582521582522088507Bacillus anthracis str. CDC 684 chromosome, complete genomecell-division initiation protein DivIVA4e-1891.3
NC_014171:3779956:380143138014313801937507Bacillus thuringiensis BMB171 chromosome, complete genomecell division protein DivIVA4e-1891.3
NC_017208:3897253:391821339182133918719507Bacillus thuringiensis serovar chinensis CT-43 chromosome, completecell division protein DivIVA4e-1891.3
NC_017200:3737185:376126637612663761772507Bacillus thuringiensis serovar finitimus YBT-020 chromosome,cell-division initiation protein1e-1790.1
NC_011969:3627980:364893236489323649438507Bacillus cereus Q1 chromosome, complete genomecell-division initiation protein diviva1e-1790.1
NC_003909:3671468:369438436943843694890507Bacillus cereus ATCC 10987, complete genomecell-division initiation protein DivIVA1e-1790.1
NC_014019:4094750:411342241134224113916495Bacillus megaterium QM B1551 chromosome, complete genomecell division initiation protein DivIVA3e-1788.2
NC_014623:6095658:611447561144756115002528Stigmatella aurantiaca DW4/3-1 chromosome, complete genomecell-division initiation protein DivIVA5e-1787.4
NC_014973:1598429:161673216167321617178447Geobacter sp. M18 chromosome, complete genomeDivIVA domain-containing protein1e-1169.7
NC_011898:3973627:400763040076304008094465Clostridium cellulolyticum H10, complete genomeDivIVA family protein3e-1065.1
NC_016629:3308329:330832933083293308832504Desulfovibrio africanus str. Walvis Bay chromosome, completeDivIVA domain-containing protein4e-1064.7
NC_011999:813978:822073822073822639567Macrococcus caseolyticus JCSC5402, complete genomecell-division initiation protein homolog1e-0963.5
NC_007350:1629694:165046916504691651071603Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305,putative cell-division initiation protein6e-0857.4
NC_010830:1451887:145662314566231457156534Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein2e-0652.4
NC_020409:363114:383249383249383752504Desulfovibrio piezophilus str. nov C1TLV30 chromosome, completeCell-division initiation protein DivIVA3e-0651.6