Pre_GI: BLASTP Hits

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Query: NC_003366:2106937:2119280 Clostridium perfringens str. 13, complete genome

Start: 2119280, End: 2120407, Length: 1128

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_021184:3793285:3809731380973138108971167Desulfotomaculum gibsoniae DSM 7213, complete genomeputative N6-adenine-specific DNA methylase2e-119429
NC_015589:626321:6440086440086451831176Desulfotomaculum ruminis DSM 2154 chromosome, complete genomerRNA (guanine-N(2)-)-methyltransferase2e-112405
NC_012778:403962:4199654199654211251161Eubacterium eligens ATCC 27750, complete genomeputative N6-adenine-specific DNA methylase6e-100364
NC_010556:1292232:1294693129469312958381146Exiguobacterium sibiricum 255-15, complete genomeputative RNA methylase4e-92338
NC_009616:183772:1922611922611932831023Thermosipho melanesiensis BI429 chromosome, complete genomeputative RNA methylase4e-55215
NC_014933:1023486:1035906103590610374111506Bacteroides helcogenes P 36-108 chromosome, complete genomerRNA (guanine-N(2)-)-methyltransferase1e-51204
NC_016602:1994110:2013620201362020157432124Vibrio furnissii NCTC 11218 chromosome 1, complete sequenceN6-adenine-specific DNA methylase5e-51202
NC_004663:4137501:4155921415592141573901470Bacteroides thetaiotaomicron VPI-5482, complete genomeputative N6-adenine-specific DNA methylase1e-50201
NC_006347:70607:9474294742960971356Bacteroides fragilis YCH46, complete genomeputative N6-adenine-specific DNA methylase9e-51201
NC_016776:66223:9035790357917121356Bacteroides fragilis 638R, complete genomeputative methylase9e-51201
NC_008095:1697157:1716791171679117180921302Myxococcus xanthus DK 1622, complete genomeTHUMP domain/methyltransferase domain protein6e-51201
NC_015707:826649:8443248443248453851062Thermotoga thermarum DSM 5069 chromosome, complete genomerRNA (guanine-N(2)-)-methyltransferase2e-50200
NC_014394:3114648:3116752311675231178971146Gallionella capsiferriformans ES-2 chromosome, complete genomerRNA (guanine-N(2)-)-methyltransferase2e-50200
NC_011205:1107998:1128363112836311304712109Salmonella enterica subsp. enterica serovar Dublin str. CT_0202185323S rRNA m(2)G2445 methyltransferase3e-50199
NC_011294:1006630:1027736102773610298442109Salmonella enterica subsp. enterica serovar Enteritidis str23S rRNA m(2)G2445 methyltransferase3e-50199
NC_013508:1351447:1367748136774813698652118Edwardsiella tarda EIB202, complete genomeputative RNA methylase3e-50199
NC_016745:2229271:2251955225195522540572103Oceanimonas sp. GK1 chromosome, complete genome23S rRNA m(2)G2445 methyltransferase9e-50197
NC_007498:2618131:2634514263451426356231110Pelobacter carbinolicus DSM 2380, complete genomepredicted N6-adenine-specific DNA methylase3e-49196
NC_015500:2866027:2870156287015628713491194Treponema brennaborense DSM 12168 chromosome, complete genomerRNA (guanine-N(2)-)-methyltransferase4e-49195
NC_009481:1927995:1943093194309319442651173Synechococcus sp. WH 7803 chromosome, complete genomeN6-adenine-specific DNA methylase5e-49195
NC_020541:2850831:2869737286973728719232187Rhodanobacter sp. 2APBS1, complete genomeputative N6-adenine-specific DNA methylase2e-48193
NC_005071:1643557:1677975167797516790991125Prochlorococcus marinus str. MIT 9313, complete genomeputative RNA methylase4e-48192
NC_015496:2371163:2391300239130023924511152Krokinobacter diaphorus 4H-3-7-5 chromosome, complete genomerRNA (guanine-N(2)-)-methyltransferase2e-47189
NC_013222:2795919:2796745279674527978811137Robiginitalea biformata HTCC2501, complete genomeputative N6-adenine-specific DNA methylase3e-47189
NC_012559:2663747:2664963266496326661231161Laribacter hongkongensis HLHK9, complete genomeprobable oxidoreductase4e-47189
NC_009348:2125698:2125698212569821278572160Aeromonas salmonicida subsp. salmonicida A449, complete genome23S rRNA m(2)G2445 methyltransferase4e-47189
NC_007513:438438:4433414433414444831143Synechococcus sp. CC9902, complete genomeputative RNA methylase1e-46187
NC_009257:775538:7943627943627965152154Francisella tularensis subsp. tularensis WY96-3418 chromosome,23S rRNA m(2)G2445 methyltransferase4e-45182
NC_009828:469778:5103675103675114341068Thermotoga lettingae TMO, complete genomeputative RNA methylase1e-44180
NC_014934:2985273:3008592300859230097551164Cellulophaga algicola DSM 14237 chromosome, complete genomerRNA (guanine-n(2)-)-methyltransferase6e-44178
NC_020126:1830147:1847981184798118492911311Myxococcus stipitatus DSM 14675, complete genomeTHUMP domain/methyltransferase domain-containing protein2e-43176
NC_007516:2037477:2063650206365020647921143Synechococcus sp. CC9605, complete genomeputative RNA methylase4e-42172
NC_005070:334952:3408583408583420241167Synechococcus sp. WH 8102, complete genomeputative RNA methylase2e-41170
NC_014658:620819:6392146392146403141101Methanothermus fervidus DSM 2088 chromosome, complete genomeRNA methylase7e-37154
NC_014323:625155:6470806470806483361257Herbaspirillum seropedicae SmR1 chromosome, complete genomeN6-adenine-specific DNA methylase3e-36153
NC_014117:442616:5112805112805125661287Burkholderia sp. CCGE1002 chromosome chromosome 1, completeputative RNA methylase5e-36152
NC_010524:4644587:4688500468850046898221323Leptothrix cholodnii SP-6, complete genomeputative RNA methylase1e-33144
NC_015677:285896:2858962858962871521257Ramlibacter tataouinensis TTB310 chromosome, complete genomeN6-adenine-specific DNA methylase1e-29130
NC_011145:4628000:464871446487144649667954Anaeromyxobacter sp. K, complete genomeputative RNA methylase7e-24111
NC_009776:707785:725116725116726099984Ignicoccus hospitalis KIN4/I, complete genomeputative RNA methylase9e-1684.7
NC_015931:134601:1531481531481541851038Pyrolobus fumarii 1A, complete genomerRNA (guanine-N(2)-)-methyltransferase1e-1171.2
NC_008818:1644223:164731316473131648203891Hyperthermus butylicus DSM 5456, complete genomehypothetical protein2e-1067
NC_008701:391216:3944133944133954171005Pyrobaculum islandicum DSM 4184, complete genomeputative RNA methylase1e-0861.2