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Query: NC_003366:2106937:2107599 Clostridium perfringens str. 13, complete genome

Start: 2107599, End: 2108483, Length: 885

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013385:1669510:167232216723221673293972Ammonifex degensii KC4, complete genomestage III sporulation protein AA2e-62239
NC_014652:1758787:176572117657211766662942Caldicellulosiruptor hydrothermalis 108 chromosome, completeaaa atpase9e-45180
NC_014721:1028841:104281710428171043758942Caldicellulosiruptor kristjanssonii 177R1B chromosome, completeaaa atpase2e-44179
NC_016048:2243108:224911422491142250019906Oscillibacter valericigenes Sjm18-20, complete genomestage III sporulation protein AA1e-41170
NC_014212:501449:510719510719511687969Meiothermus silvanus DSM 9946 chromosome, complete genomeAAA ATPase1e-1790.5
NC_009925:1617414:1622297162229716240301734Acaryochloris marina MBIC11017, complete genomehypothetical protein8e-1787.8
NC_013771:1171251:1173886117388611756581773Cyanobacterium UCYN-A, complete genomehypothetical protein3e-1479.3
NC_014974:1539950:155200415520041552954951Thermus scotoductus SA-01 chromosome, complete genomeAAA ATPase9e-1477.8
NC_007484:3358000:3361668336166833631581491Nitrosococcus oceani ATCC 19707, complete genomeSingle-stranded nucleic acid binding R3H1e-1273.9
NC_014315:3207684:3211981321198132134711491Nitrosococcus watsoni C-113 chromosome, complete genomesingle-stranded nucleic acid-binding R3H domain-containing protein2e-1273.2
NC_017030:9818064:9824320982432098260141695Corallococcus coralloides DSM 2259 chromosome, complete genomehypothetical protein6e-1271.6
NC_011884:393328:4088134088134105671755Cyanothece sp. PCC 7425, complete genomesingle-stranded nucleic acid binding R3H domain protein8e-1167.8
NC_008820:2027977:2030586203058620322231638Prochlorococcus marinus str. MIT 9303, complete genomeAAA ATPase superfamily protein4e-1065.9