Pre_GI: BLASTP Hits

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Query: NC_003366:2057656:2079948 Clostridium perfringens str. 13, complete genome

Start: 2079948, End: 2080928, Length: 981

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:1950205:196869819686981969678981Clostridium perfringens SM101, complete genomeoxidoreductase family protein0654
NC_010674:2435241:245199224519922452981990Clostridium botulinum B str. Eklund 17B, complete genomeelectron transfer subunit protein4e-109394
NC_014393:2771774:280041928004192801399981Clostridium cellulovorans 743B chromosome, complete genomehypothetical protein8e-81300
NC_010320:1585974:159629715962971597268972Thermoanaerobacter sp. X514 chromosome, complete genomehypothetical protein1e-68259
NC_014538:1311500:131711413171141318085972Thermoanaerobacter sp. X513 chromosome, complete genomehypothetical protein1e-68259
NC_014964:1169925:118201911820191182990972Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completehypothetical protein1e-60233
NC_010321:1177238:118982811898281190799972Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completehypothetical protein1e-60233
NC_012563:2597934:261360626136062614307702Clostridium botulinum A2 str. Kyoto, complete genomeoxidoreductase family protein7e-60231
NC_014033:1564733:158086715808671581829963Prevotella ruminicola 23 chromosome, complete genomeiron-sulfur cluster-binding protein3e-57222
NC_021182:1654903:166216016621601662900741Clostridium pasteurianum BC1, complete genome2-polyprenylphenol hydroxylase-like oxidoreductase2e-1067
NC_014410:1527405:154127815412781542009732Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,oxidoreductase FAD/NAD(P)-binding domain protein5e-1065.5
NC_019970:1457794:147668814766881477419732Thermoanaerobacterium thermosaccharolyticum M0795, complete genome2-polyprenylphenol hydroxylase-like oxidoreductase1e-0963.9
NC_009697:3409185:342312034231203423875756Clostridium botulinum A str. ATCC 19397 chromosome, completedihydroorotate dehydrogenase electron transfer subunit2e-0860.1
NC_014393:1901688:191945719194571920191735Clostridium cellulovorans 743B chromosome, complete genomeDihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain4e-0858.9
NC_000868:1730820:173201217320121732755744Pyrococcus abyssi GE5, complete genomedihydroorotate dehydrogenase electron transfer subunit4e-0755.8
NC_015516:1222632:123197212319721232754783Melissococcus plutonius ATCC 35311, complete genomedihydroorotate dehydrogenase electron transfersubunit6e-0755.1
NC_013517:2815482:283219228321922833007816Sebaldella termitidis ATCC 33386, complete genomeoxidoreductase FAD/NAD(P)-binding domain protein2e-0653.1
NC_015499:309394:309394309394310119726Thermodesulfobium narugense DSM 14796 chromosome, complete genomeoxidoreductase FAD/NAD(P)-binding domain protein3e-0653.1
NC_003212:1958500:196322919632291963993765Listeria innocua Clip11262, complete genomepyrDII4e-0652.8
NC_003413:181525:198787198787199530744Pyrococcus furiosus DSM 3638, complete genomedihydroorotate dehydrogenase electron transfer subunit8e-0651.6