Pre_GI: BLASTP Hits

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Query: NC_003366:2057656:2070069 Clostridium perfringens str. 13, complete genome

Start: 2070069, End: 2071082, Length: 1014

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:1950205:1959420195942019604331014Clostridium perfringens SM101, complete genomemolybdenum cofactor biosynthesis protein, putative2e-171601
NC_009617:2304390:2312703231270323137221020Clostridium beijerinckii NCIMB 8052 chromosome, complete genomemolybdopterin binding domain-containing protein8e-104377
NC_010001:1806000:1822057182205718230821026Clostridium phytofermentans ISDg, complete genomemolybdopterin binding domain1e-98359
NC_010674:1170264:1190918119091811919401023Clostridium botulinum B str. Eklund 17B, complete genomemolybdopterin biosynthesis protein2e-97355
NC_020291:744329:7544167544167554381023Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomemolybdenum cofactor cytidylyltransferase MoeA5e-94344
NC_018870:115982:1481951481951492201026Thermacetogenium phaeum DSM 12270 chromosome, complete genomemolybdopterin biosynthesis protein2e-89329
NC_009454:1577319:1624626162462616256541029Pelotomaculum thermopropionicum SI, complete genomemolybdopterin biosynthesis enzyme2e-83308
NC_009454:1577319:1604226160422616052601035Pelotomaculum thermopropionicum SI, complete genomemolybdopterin biosynthesis enzyme3e-82305
NC_013216:3625830:3641848364184836428701023Desulfotomaculum acetoxidans DSM 771, complete genomemolybdopterin binding domain protein8e-82303
NC_006138:1921424:1936131193613119371531023Desulfotalea psychrophila LSv54, complete genomemolybdopterin biosynthesis protein5e-81301
NC_006138:273237:2928002928002939121113Desulfotalea psychrophila LSv54, complete genomemolybdopterin biosynthesis protein1e-80300
NC_002937:1634287:1639590163959016406091020Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough, completemolybdopterin biosynthesis protein, putative3e-80298
NC_008751:1851358:1865847186584718668661020Desulfovibrio vulgaris subsp. vulgaris DP4, complete genomemolybdopterin binding domain3e-80298
NC_020409:1956485:1972906197290619739221017Desulfovibrio piezophilus str. nov C1TLV30 chromosome, completeputative molybdopterin biosynthesis protein5e-80298
NC_014972:3227500:3244101324410132451441044Desulfobulbus propionicus DSM 2032 chromosome, complete genomemolybdenum cofactor cytidylyltransferase1e-75283
NC_018664:3009166:3040953304095330419721020Clostridium acidurici 9a chromosome, complete genomemolybdopterin binding domain-containing protein3e-71268
NC_013520:1905554:190847319084731909453981Veillonella parvula DSM 2008, complete genomemolybdopterin binding domain protein6e-68258
NC_021182:401129:402139402139403113975Clostridium pasteurianum BC1, complete genomemolybdopterin biosynthesis enzyme1e-55217
NC_010718:2337209:2347769234776923489981230Natranaerobius thermophilus JW/NM-WN-LF, complete genomemolybdopterin binding domain6e-55214
NC_015151:1218390:123339312333931234388996Vulcanisaeta moutnovskia 768-28 chromosome, complete genomemolybdopterin binding domain3e-42172
NC_009523:1025556:102555610255561026548993Roseiflexus sp. RS-1 chromosome, complete genomemolybdopterin binding domain-containing protein9e-26117
NC_014006:1862000:186611718661171867109993Sphingobium japonicum UT26S chromosome 1, complete genomeputative molybdopterin biosynthesis enzyme3e-1582.8
NC_014926:819163:835770835770836681912Thermovibrio ammonificans HB-1 chromosome, complete genomemolybdenum cofactor biosynthesis protein C3e-0756.6
NC_019791:1154816:1161724116172411636731950Caldisphaera lagunensis DSM 15908 chromosome, complete genomemolybdenum cofactor synthesis domain-containing protein4e-0756.2
NC_014632:1404000:1423622142362214248151194Ilyobacter polytropus DSM 2926 chromosome, complete genomemolybdenum cofactor synthesis domain-containing protein1e-0654.7
NC_011830:1504497:151040715104071510907501Desulfitobacterium hafniense DCB-2, complete genomemolybdenum cofactor synthesis domain protein1e-0653.9
NC_014328:773095:7794707794707806691200Clostridium ljungdahlii ATCC 49587 chromosome, complete genomemolybdenum cofactor biosynthesis protein MoeA3e-0652.8
NC_007644:2205599:2233430223343022346531224Moorella thermoacetica ATCC 39073, complete genomeMolybdopterin binding domain4e-0652.4
NC_010943:2815865:281853328185332819498966Stenotrophomonas maltophilia K279a, complete genomeputative molybdenum cofactor biosynthesis protein (putative secreted protein)7e-0651.6
NC_010718:464405:4706714706714725991929Natranaerobius thermophilus JW/NM-WN-LF, complete genomemolybdenum cofactor synthesis domain protein8e-0651.6
NC_013769:123958:1432691432691449091641Sulfolobus islandicus L.D.8.5 chromosome, complete genomemolybdenum cofactor synthesis domain-containing protein9e-0651.6