Pre_GI: BLASTP Hits

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Query: NC_003366:1901898:1919598 Clostridium perfringens str. 13, complete genome

Start: 1919598, End: 1920884, Length: 1287

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008261:2117207:2134911213491121361971287Clostridium perfringens ATCC 13124, complete genomehypothetical protein0712
NC_008262:1795914:1808961180896118102471287Clostridium perfringens SM101, complete genomehypothetical protein0698
NC_012563:2979147:2998706299870629999051200Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein9e-67254
NC_009697:2680607:2697530269753026987291200Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein1e-65250
NC_015425:906969:9084169084169097351320Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein9e-61234
NC_008593:841291:8427408427408440711332Clostridium novyi NT, complete genomePredicted membrane protein7e-59228
NC_010723:2735196:2750889275088927521901302Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein1e-58227
NC_010674:2930259:2946576294657629478801305Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein3e-57223
NC_010718:3039434:3043822304382230456601839Natranaerobius thermophilus JW/NM-WN-LF, complete genomeGlucose/sorbosone dehydrogenase-like protein2e-25117