Pre_GI: BLASTP Hits

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Query: NC_003366:1901898:1916667 Clostridium perfringens str. 13, complete genome

Start: 1916667, End: 1916993, Length: 327

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008261:2117207:213198021319802132306327Clostridium perfringens ATCC 13124, complete genomeATP synthase-like protein4e-52202
NC_008262:1795914:180603018060301806356327Clostridium perfringens SM101, complete genomehypothetical protein1e-51201
NC_010723:2735196:274795327479532748279327Clostridium botulinum E3 str. Alaska E43, complete genomeV-type sodium ATP synthase subunit G5e-1683.2
NC_010674:2930259:294364029436402943966327Clostridium botulinum B str. Eklund 17B, complete genomeV-type sodium ATP synthase subunit G6e-1682.8
NC_008593:841291:847460847460847795336Clostridium novyi NT, complete genomeV-type sodium ATP synthase subunit G3e-1477
NC_009697:2680607:269375626937562694082327Clostridium botulinum A str. ATCC 19397 chromosome, completeV-type ATPase, G subunit3e-1477
NC_015425:906969:913079913079913405327Clostridium botulinum BKT015925 chromosome, complete genomeV-type sodium ATP synthase subunit G1e-1375.5
NC_012563:2979147:299490829949082995234327Clostridium botulinum A2 str. Kyoto, complete genomeputative V-type ATPase, G subunit3e-1373.6