Pre_GI: BLASTP Hits

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Query: NC_003366:1901898:1912234 Clostridium perfringens str. 13, complete genome

Start: 1912234, End: 1912551, Length: 318

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:1795914:180159518015951801912318Clostridium perfringens SM101, complete genomeV-type ATPase, G subunit1e-54211
NC_008261:2117207:212754421275442127861318Clostridium perfringens ATCC 13124, complete genomeV-type ATPase, G subunit1e-54211
NC_010674:2930259:293924729392472939558312Clostridium botulinum B str. Eklund 17B, complete genomeATP synthase (F/14-kDa) subunit8e-45178
NC_010723:2735196:274356027435602743871312Clostridium botulinum E3 str. Alaska E43, complete genomeV-type ATPase, G subunit8e-45178
NC_008593:841291:851968851968852276309Clostridium novyi NT, complete genomeATP synthase (F/14-kDa) subunit4e-42169
NC_012563:2979147:299051629905162990833318Clostridium botulinum A2 str. Kyoto, complete genomeV-type ATPase, G subunit1e-39161
NC_015425:906969:917572917572917880309Clostridium botulinum BKT015925 chromosome, complete genomeV-type ATPase, G subunit1e-39161
NC_009697:2680607:268936426893642689672309Clostridium botulinum A str. ATCC 19397 chromosome, completeV-type ATP synthase subunit F6e-39159
NC_013192:815854:826778826778827086309Leptotrichia buccalis DSM 1135, complete genomeVacuolar H+transporting two-sector ATPase F subunit4e-33139
NC_013921:2375900:238756023875602387889330Thermoanaerobacter italicus Ab9 chromosome, complete genomeVacuolar H+transporting two-sector ATPase F subunit7e-24109
NC_014209:2257316:226897822689782269307330Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,Vacuolar H+transporting two-sector ATPase F subunit8e-24108
NC_010320:2397395:240937224093722409707336Thermoanaerobacter sp. X514 chromosome, complete genomeV-type ATP synthase subunit F8e-24108
NC_010321:2319820:233012023301202330455336Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeV-type ATP synthase subunit F8e-24108
NC_014538:2396559:240853624085362408865330Thermoanaerobacter sp. X513 chromosome, complete genomeVacuolar H+transporting two-sector ATPase subunit F4e-23106
NC_014964:2301835:231213523121352312464330Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeVacuolar H+transporting two-sector ATPase subunit F4e-23106
NC_014377:2033781:205574720557472056076330Thermosediminibacter oceani DSM 16646 chromosome, complete genomeVacuolar H+transporting two-sector ATPase F subunit8e-23105
NC_013315:3214063:322337132233713223694324Clostridium difficile CD196 chromosome, complete genomeV-type ATP synthase subunit F9e-2095.5
NC_017179:3222015:323132332313233231640318Clostridium difficile BI1, complete genomeV-type ATP synthase subunit F1e-1995.1
NC_009785:130252:138111138111138431321Streptococcus gordonii str. Challis substr. CH1, complete genomeATP synthase (F/14-kDa) subunit7e-1992.8
NC_015574:2057602:206856420685642068884321Methanobacterium sp. SWAN-1 chromosome, complete genomeV-type ATP synthase subunit F4e-1063.2
NC_016148:1021138:102214110221411022482342Thermovirga lienii DSM 17291 chromosome, complete genomeVacuolar H+transporting two-sector ATPase F subunit2e-0858.2
NC_007681:1300068:130903313090331309353321Methanosphaera stadtmanae DSM 3091, complete genomeAhaF2e-0754.3
NC_015216:405657:414387414387414707321Methanobacterium sp. AL-21 chromosome, complete genomeV-type ATP synthase subunit F2e-0651.2
NC_000909:201000:209008209008209304297Methanocaldococcus jannaschii DSM 2661, complete genomeV-type ATP synthase subunit F3e-0650.4
NC_015562:627000:636545636545636850306Methanotorris igneus Kol 5 chromosome, complete genomeV-type ATP synthase subunit F9e-0648.9