Pre_GI: BLASTP Hits

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Query: NC_003366:1901898:1904439 Clostridium perfringens str. 13, complete genome

Start: 1904439, End: 1904834, Length: 396

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008261:2117207:211974921197492120144396Clostridium perfringens ATCC 13124, complete genomeribose ABC transporter, ribose-binding protein5e-43172
NC_008593:1797000:181901718190171819412396Clostridium novyi NT, complete genomeribose ABC transporter protein RbsD1e-34145
NC_015425:2024154:204577020457702046165396Clostridium botulinum BKT015925 chromosome, complete genomeribose ABC transporter protein RbsD1e-34144
NC_004557:2475030:249155124915512491946396Clostridium tetani E88, complete genomehigh affinity ribose transport protein rbsD5e-34142
NC_016614:686887:699051699051699470420Vibrio sp. EJY3 chromosome 2, complete sequenceD-ribose pyranase1e-1995.5
NC_012214:1:253832538325802420Erwinia pyrifoliae Ep1/96, complete genomeD-ribose high-affinity transport system8e-2095.5
NC_010320:143109:163609163609164001393Thermoanaerobacter sp. X514 chromosome, complete genomeD-ribose pyranase2e-1994.4
NC_014538:187747:203474203474203866393Thermoanaerobacter sp. X513 chromosome, complete genomeRbsD or FucU transport2e-1994.4
NC_011772:647778:655881655881656276396Bacillus cereus G9842, complete genomeribose ABC transporter protein4e-1993.2
NC_017208:671128:680051680051680446396Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeD-ribose pyranase4e-1993.2
NC_011969:726369:733401733401733796396Bacillus cereus Q1 chromosome, complete genomed-ribose pyranase4e-1993.2
NC_016771:701909:711761711761712156396Bacillus cereus NC7401, complete genomeribose ABC transporter protein4e-1993.2
NC_004722:650950:657537657537657932396Bacillus cereus ATCC 14579, complete genomeHigh affinity ribose transport protein rbsD6e-1992.8
NC_010184:661226:669170669170669565396Bacillus weihenstephanensis KBAB4, complete genomeRbsD or FucU transport1e-1892
NC_011725:681387:687974687974688369396Bacillus cereus B4264 chromosome, complete genomeD-ribose pyranase1e-1892
NC_004337:3590323:394205639420563942475420Shigella flexneri 2a str. 301, complete genomeD-ribose high-affinity transport system; membrane-associated protein9e-1992
NC_006274:659922:672436672436672831396Bacillus cereus E33L, complete genomeribose ABC transporter, permease2e-1890.9
NC_007530:674265:684105684105684500396Bacillus anthracis str. 'Ames Ancestor', complete genomeribose abc transporter protein2e-1890.9
NC_005945:674337:684000684000684395396Bacillus anthracis str. Sterne, complete genomeribose ABC transporter protein2e-1890.9
NC_003997:674265:684104684104684499396Bacillus anthracis str. Ames, complete genomeribose ABC transporter protein2e-1890.9
NC_005957:667954:674987674987675382396Bacillus thuringiensis serovar konkukian str. 97-27, completeribose ABC transporter, permease2e-1890.9
NC_011773:688689:698542698542698937396Bacillus cereus AH820 chromosome, complete genomeD-ribose pyranase2e-1890.9
NC_012659:678289:684005684005684400396Bacillus anthracis str. A0248, complete genomeD-ribose pyranase2e-1890.9
NC_016779:657568:665514665514665909396Bacillus cereus F837/76 chromosome, complete genomeRibose ABC transporter high affinity permease RbsD2e-1890.9
NC_010556:2328303:234760123476012347990390Exiguobacterium sibiricum 255-15, complete genomeRbsD or FucU transport5e-1889.7
NC_018665:2163713:218550121855012185890390Exiguobacterium antarcticum B7 chromosome, complete genomeD-ribose pyranase5e-1786.3
NC_017095:166896:168375168375168761387Fervidobacterium pennivorans DSM 9078 chromosome, complete genomeABC-type ribose transport system, auxiliary component1e-1685.1
NC_012785:638000:648054648054648452399Kosmotoga olearia TBF 19.5.1, complete genomeRbsD or FucU transport1e-1684.7
NC_015161:1556766:156242115624211562816396Deinococcus proteolyticus MRP chromosome, complete genomeD-ribose pyranase3e-1683.6
NC_014039:15236:222032220322586384Propionibacterium acnes SK137 chromosome, complete genomeRibose ABC transport system, high affinity permease RbsD1e-1582
NC_016511:15100:220682206822451384Propionibacterium acnes TypeIA2 P.acn31 chromosome, completeD-ribose pyranase9e-1682
NC_016512:15102:220702207022453384Propionibacterium acnes TypeIA2 P.acn17 chromosome, completeD-ribose pyranase9e-1682
NC_016516:15102:220702207022453384Propionibacterium acnes TypeIA2 P.acn33 chromosome, completeD-ribose pyranase9e-1682
NC_006085:15246:222142221422597384Propionibacterium acnes KPA171202, complete genomehigh affinity ribose transport protein RbsD9e-1682
NC_015589:1468774:148905014890501489448399Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeRbsD or FucU transport8e-1579
NC_013205:2332174:234225723422572342652396Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,RbsD or FucU transport9e-1475.5
NC_016113:11500:286142861429003390Streptomyces cattleya NRRL 8057 plasmid pSCAT, complete sequenceribose ABC transporter (membrane bound ribose binding)4e-1373.6
NC_011978:1581994:158610815861081586515408Thermotoga neapolitana DSM 4359, complete genomeRibose ABC transporter, membrane-associated protein5e-1373.2
NC_000853:960248:976804976804977211408Thermotoga maritima MSB8, complete genomeribose ABC transporter, membrane-associated protein5e-1373.2
NC_013721:1581370:159709915970991597494396Gardnerella vaginalis 409-05, complete genomeRbsD/FucU transport family protein6e-1372.8
NC_021177:7159654:718079171807917181180390Streptomyces fulvissimus DSM 40593, complete genomeD-ribose pyranase 2 n11e-1168.9
NC_008148:1859888:191606419160641916528465Rubrobacter xylanophilus DSM 9941, complete genomeRbsD or FucU transport2e-1168.2
NC_017218:1655009:167606016760601676455396Bifidobacterium breve ACS-071-V-Sch8b chromosome, complete genomeRbsD/FucU transport family protein1e-0858.5
NC_014169:1784435:181122018112201811615396Bifidobacterium longum subsp. longum JDM301 chromosome, completeRbsD/FucU transport family protein5e-0856.2
NC_013521:107937:112705112705113088384Sanguibacter keddieii DSM 10542, complete genomeABC-type ribose transport system, auxiliary component3e-0753.9