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Query: NC_003155:590500:602829 Streptomyces avermitilis MA-4680, complete genome

Start: 602829, End: 603446, Length: 618

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009664:4377777:439449243944924395079588Kineococcus radiotolerans SRS30216, complete genometranscriptional regulator, TetR family9e-45179
NC_015711:7471500:747851474785147479170657Myxococcus fulvus HW-1 chromosome, complete genomeTetR family transcriptional regulator4e-1374.7
NC_008095:5527707:553484855348485535489642Myxococcus xanthus DK 1622, complete genometranscriptional regulator, TetR family7e-1373.9
NC_020126:6344827:635200863520086352640633Myxococcus stipitatus DSM 14675, complete genomeTetR family transcriptional regulator4e-1271.2
NC_016109:954538:970248970248970856609Kitasatospora setae KM-6054, complete genomeputative TetR family transcriptional regulator6e-1270.9
NC_019673:6473743:647426064742606474844585Saccharothrix espanaensis DSM 44229 complete genomeTranscriptional regulator, TetR family2e-0962
NC_016113:1143580:115842411584241159002579Streptomyces cattleya NRRL 8057 plasmid pSCAT, complete sequencetranscriptional regulator4e-0961.2
NC_016947:2210339:221402822140282214624597Mycobacterium intracellulare MOTT-02 chromosome, complete genomeTetR family transcriptional regulator2e-0859.3
NC_003155:210240:240325240325240903579Streptomyces avermitilis MA-4680, complete genomeTetR-family transcriptional regulator5e-0754.7
NC_016111:5369414:538947253894725390089618Streptomyces cattleya NRRL 8057, complete genomeTetR-family transcriptional regulator2e-0652.8
NC_002944:1881405:188687318868731887457585Mycobacterium avium subsp. paratuberculosis K-10, complete genomehypothetical protein3e-0652
NC_016641:438500:455047455047455622576Paenibacillus terrae HPL-003 chromosome, complete genomeTetR family transcriptional regulator3e-0651.6
NC_011768:3385719:341889634188963419528633Desulfatibacillum alkenivorans AK-01, complete genometranscriptional regulator, TetR family4e-0651.2
NC_017904:2162045:216572721657272166323597Mycobacterium sp. MOTT36Y chromosome, complete genomeTetR family transcriptional regulator4e-0651.2