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Query: NC_003143:2309500 Yersinia pestis CO92, complete genome

Start: 2309500, End: 2328981, Length: 19482

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_004088:2491303*2491303251808626784Yersinia pestis KIM, complete genome017790BLASTN svgBLASTP svg
NC_008150:1593500*1593500161559922100Yersinia pestis Antiqua, complete genome017770BLASTN svgBLASTP svg
NC_005810:2091930*2091930210959917670Yersinia pestis biovar Microtus str. 91001, complete genome017770BLASTN svgBLASTP svg
NC_008149:1718000*1718000173562917630Yersinia pestis Nepal516, complete genome017770BLASTN svgBLASTP svg
NC_010465:2383219*2383219240542422206Yersinia pseudotuberculosis YPIII, complete genome016240BLASTN svgBLASTP svg
NC_006155:2378526*2378526239794819423Yersinia pseudotuberculosis IP 32953, complete genome014310BLASTN svgBLASTP svg
NC_010634:2297000*2297000231809921100Yersinia pseudotuberculosis PB1/+, complete genome013830BLASTN svgBLASTP svg
NC_010159:2546590*2546590256968123092Yersinia pestis Angola, complete genome012970BLASTN svgBLASTP svg
NC_004547:2810151*2810151283724527095Erwinia carotovora subsp. atroseptica SCRI1043, complete genome1e-57232BLASTN svgBLASTP svg
NC_014562:1772842*1772842180089428053Pantoea vagans C9-1 chromosome, complete genome7e-56226BLASTN svgBLASTP svg
NC_008258:1934479*1934479196306928591Shigella flexneri 5 str. 8401, complete genome1e-51212BLASTN svgBLASTP svg
NC_007384:1320287*1320287134781127525Shigella sonnei Ss046, complete genome1e-26129BLASTN svgBLASTP svg
NC_009348:3029963*3029963306659936637Aeromonas salmonicida subsp. salmonicida A449, complete genome9e-0660BLASTN svgBLASTP svg
NC_008463:5364428*5364428539303028603Pseudomonas aeruginosa UCBPP-PA14, complete genome9e-0660BLASTN svgBLASTP svg