Pre_GI: BLASTP Hits

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Query: NC_003143:675622:682877 Yersinia pestis CO92, complete genome

Start: 682877, End: 683203, Length: 327

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:3790750:380268838026883803023336Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein8e-48188
NC_004088:3923804:393732739373273937662336Yersinia pestis KIM, complete genomehypothetical protein8e-48188
NC_010634:4001154:401614640161464016481336Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein8e-48188
NC_008149:587689:594411594411594746336Yersinia pestis Nepal516, complete genomehypothetical protein8e-48188
NC_005810:3272765:327570932757093276044336Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein8e-48188
NC_006155:4062000:407591340759134076248336Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein8e-48188
NC_008150:3495851:351022835102283510563336Yersinia pestis Antiqua, complete genomehypothetical protein8e-48188
NC_010465:660207:663151663151663486336Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein8e-48188
NC_009381:460358:464833464833465168336Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein8e-48188
NC_009708:633054:635998635998636324327Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein1e-47187
NC_010159:1071937:108324610832461083428183Yersinia pestis Angola, complete genomehypothetical protein1e-1994.7
NC_010515:2691000:272541527254152725708294Burkholderia cenocepacia MC0-3 chromosome 2, complete sequencehypothetical protein2e-0651.6
NC_007511:1147696:118438711843871184680294Burkholderia sp. 383 chromosome 2, complete sequencehypothetical protein2e-0651.6
NC_015376:2010009:203563320356332035932300Burkholderia gladioli BSR3 chromosome chromosome 2, completehypothetical protein9e-0648.9