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Query: NC_003143:675622:679933 Yersinia pestis CO92, complete genome

Start: 679933, End: 681702, Length: 1770

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005810:3272765:3272765327276532745851821Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein01127
NC_008149:587689:5914675914675933681902Yersinia pestis Nepal516, complete genomemembrane protein01127
NC_004088:3923804:3938705393870539406061902Yersinia pestis KIM, complete genomehypothetical protein01127
NC_008150:3495851:3511606351160635135071902Yersinia pestis Antiqua, complete genomehypothetical protein01127
NC_009381:460358:4618894618894637901902Yersinia pestis Pestoides F chromosome, complete genomemembrane protein01127
NC_014029:729675:7334537334537353541902Yersinia pestis Z176003 chromosome, complete genomehypothetical protein01127
NC_017154:671816:6755946755946774951902Yersinia pestis D106004 chromosome, complete genomehypothetical protein01127
NC_017160:676249:6777796777796796801902Yersinia pestis D182038 chromosome, complete genomehypothetical protein01127
NC_017265:3790750:3804066380406638059671902Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein01127
NC_010634:4001154:4017524401752440194251902Yersinia pseudotuberculosis PB1/+, complete genomefusaric acid resistance protein region01124
NC_010465:660207:6602076602076621081902Yersinia pseudotuberculosis YPIII, complete genomeFusaric acid resistance protein conserved region01123
NC_009708:633054:6330546330546349551902Yersinia pseudotuberculosis IP 31758 chromosome, complete genomefusaric acid resistance domain-containing protein01123
NC_006155:4062000:4077291407729140791921902Yersinia pseudotuberculosis IP 32953, complete genomepossible PET family efflux transporter01121
NC_007511:1147696:1181039118103911833602322Burkholderia sp. 383 chromosome 2, complete sequencemembrane protein-like2e-62241
NC_007509:3668:3972439724418502127Burkholderia sp. 383 chromosome 3, complete sequenceFusaric acid resistance protein2e-44180
CP002185:4566150:4566150456615045682012052Escherichia coli W, complete genomepredicted outer membrane factor of efflux pump1e-32141
NC_013364:5040268:5040268504026850423192052Escherichia coli O111:H- str. 11128, complete genomeputative multidrug efflux system component1e-32141
NC_009800:4332229:4332229433222943342802052Escherichia coli HS, complete genomemultidrug resistance protein MdtO4e-32139
NC_007613:4156841:4156841415684141587511911Shigella boydii Sb227, complete genomeputative enzyme7e-32139
NC_015376:2010009:2036959203695920391482190Burkholderia gladioli BSR3 chromosome chromosome 2, completefusaric acid resistance protein region1e-1895.1
NC_010515:2691000:2722322272232227243882067Burkholderia cenocepacia MC0-3 chromosome 2, complete sequencefusaric acid resistance protein conserved region9e-1892.4