Pre_GI: BLASTP Hits

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Query: NC_003143:675622:675622 Yersinia pestis CO92, complete genome

Start: 675622, End: 676104, Length: 483

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004088:3923804:394443539444353944950516Yersinia pestis KIM, complete genomehypothetical protein1e-80298
NC_008150:3495851:351733635173363517851516Yersinia pestis Antiqua, complete genomehypothetical protein1e-80298
NC_010159:1071937:109020210902021090717516Yersinia pestis Angola, complete genomehypothetical protein1e-80298
NC_010634:4001154:402327340232734023785513Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein6e-80295
NC_006155:4062000:408302140830214083536516Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein2e-79294
NC_019978:224619:227848227848228375528Halobacteroides halobius DSM 5150, complete genomehypothetical protein6e-0753.1